ASTHMA AND RHINOSINUSITIS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。一项前瞻性队列研究，旨在确定哮喘的存在与上气道疾病活动性标志物之间的关系。在哮喘中发生的上气道和下气道疾病之间存在密切的病理生理学关系。然而，并非所有哮喘患者都会报告鼻炎/鼻窦炎：我们预计那些没有症状的患者可能只是患有亚临床疾病。我们将通过测量伴有和不伴有上气道疾病症状的哮喘患者的上气道炎症标志物和功能变化，确定上气道疾病是否是所有哮喘患者的特征。我们将哮喘患者与正常非哮喘受试者进行比较。我们还将测量下呼吸道的炎症标志物和功能变化，以确定这些指标是否与上呼吸道疾病活动的标志物相关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A prospective cohort study to establish the relationship between the presence of asthma and markers of disease activity in the upper airway. There is a close pathophysiological relationship between the upper and lower airway disease that occurs in asthma. However, not all asthmatics report rhinitis/sinusitis: we anticipate those without symptoms may simply have subclinical disease. We will establish if upper airway disease is a characteristic of all asthmatics, by measuring inflammatory markers and functional changes in the upper airway of asthmatics with and without symptoms of upper airway disease. We will compare asthmatics to normal non-asthmatic subjects. We will also measure inflammatory markers and functional changes in the lower airway to determine if these measures correlate with markers of upper airway disease activity.