WEIGHT LOSS AND ASTHMA

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。流行病学和基础科学研究有非常有力的证据表明，肥胖可能会影响哮喘。这对美国民众的健康有着非常重要的影响。了解体重减轻引起的生理和炎症变化将有助于我们理解肥胖与哮喘之间的关系。我们建议对一组接受胃旁路手术治疗病态肥胖的哮喘患者进行前瞻性试验。我们将测量体重减轻引起的生理和炎症变化。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There is very strong evidence from epidemiological and basic science studies to suggest that obesity may affect asthma. This has very important implications for the health of the US population. Understanding the physiological and inflammatory changes induced by weight loss would make an important contribution to our understanding of the relationship between obesity and asthma. We propose a prospective trial of a cohort of asthmatics undergoing gastric-bypass surgery for morbid obesity. We will measure physiological and inflammatory changes induced by weight loss.