THE REGISTRY FOR THE ANTIPHOSPHOLIPID SYNDROME

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。抗磷脂综合征的特征是存在与凝血病（高凝状态）相关的抗磷脂抗体，伴静脉和动脉血栓形成。原因不明，负责的抗体也不完全清楚。本研究拟收集1000例SLE综合征患者和2000例SLE抗体阳性但无血栓形成患者的血清、DNA及相关临床资料，建立数据库，以更好地了解其危险因素。这是一个知之甚少的现象，这种登记和样本收集可能是这一领域研究人员的宝贵资源。访问由一个适当的委员会管理。研究已启动，入组仍在继续。结果尚未公布。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The anti-phospholipid syndrome is characterized by the presence of antibodies against phospholipids associated with a coagulopathy (hypercoagulable state) with both venous and arterial thromboses. The cause is unknown and the responsible antibodies are not totally clear. This is a proposal to collect sera, DNA, and relevant clinical information from 1000 patients with the syndrome, 2000 SLE patients with the antibodies but without thrombosis, and to establish a database to better understand risk factors. This is a poorly understood phenomenon, and this registry and sample collection could be an invaluable resource for investigators in this area. Access is regulated by an appropriate committee. The study has been initiated, and enrollment continues. Results are not yet available.