THE REGISTRY FOR THE ANTIPHOSPHOLIPID SYNDROME

抗磷脂综合征登记处

• 批准号: 7378278
• 负责人: JOAN T. MERRILL
• 金额: $ 0.05万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7378278
• 关键词: REGISTRY; ANTIPHOSPHOLIPID; SYNDROME

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The anti-phospholipid syndrome is characterized by the presence of antibodies against phospholipids associated with a coagulopathy (hypercoagulable state) with both venous and arterial thromboses. The cause is unknown and the responsible antibodies are not totally clear. This is a proposal to collect sera, DNA, and relevant clinical information from 1000 patients with the syndrome, 2000 SLE patients with the antibodies but without thrombosis, and to establish a database to better understand risk factors. This is a poorly understood phenomenon, and this registry and sample collection could be an invaluable resource for investigators in this area. Access is regulated by an appropriate committee. The study has been initiated, and enrollment continues. Results are not yet available.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。抗磷脂综合征的特征在于存在与与凝血病（高凝状态）有关静脉和动脉血栓形成的抗磷脂的抗体。原因是未知的，负责的抗体尚不完全清楚。这是从1000名患有抗体但没有血栓形成的综合症患者的患者中收集血清，DNA和相关临床信息的建议，并建立数据库以更好地了解危险因素。这是一种鲜为人知的现象，对于该领域的研究人员而言，此注册表和样本收集可能是宝贵的资源。访问由适当的委员会监管。该研究已开始，并继续入学。结果尚不可用。