WOMEN & INFANTS TRANSMISSION STUDY III (HIV)

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。该项目旨在评估怀孕对感染艾滋病毒妇女健康的影响、艾滋病毒垂直传播的机制和时间、母婴传播率（总体和感染艾滋病毒高危孕妇的不同分组），并了解与围产期艾滋病毒传播有关的辅助因素。另一个假设是评价处方抗逆转录病毒治疗（母亲或婴儿）的安全性，特别强调线粒体毒性和葡萄糖和脂质代谢。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The project is designed to evaluate the impact of pregnancy on the health of HIV-infected women, the mechanisms and timing of vertical HIV transmission, rates of maternal-infant transmission (overall and among different subpupolations of at-risk pregnant HIV-infected women) and to understand the co-factors related to perinatal HIV transmission. An additional hypotheses is to evaluate the safety of prescribed antiretroviral therapy (maternal or infant) with specific emphasis on mitochondrial toxicity and glucose and lipid metabolism.