WOMEN & INFANTS TRANSMISSION STUDY III (HIV)

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该项目旨在评估怀孕对艾滋病毒感染妇女健康的影响、艾滋病毒垂直传播的机制和时间、母婴传播率(总体和高危孕妇感染艾滋病毒的不同群体之间的传播率)，并了解与围产期艾滋病毒传播有关的共同因素。另一个假设是评估开出的抗逆转录病毒疗法(孕妇或婴儿)的安全性，特别强调线粒体毒性和糖脂代谢。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The project is designed to evaluate the impact of pregnancy on the health of HIV-infected women, the mechanisms and timing of vertical HIV transmission, rates of maternal-infant transmission (overall and among different subpupolations of at-risk pregnant HIV-infected women) and to understand the co-factors related to perinatal HIV transmission. An additional hypotheses is to evaluate the safety of prescribed antiretroviral therapy (maternal or infant) with specific emphasis on mitochondrial toxicity and glucose and lipid metabolism.