EFFECTS OF MARIJUANA ON BRAIN DEVELOPMENT

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。这是一项对（N=30）年轻成年人（18-24）大麻使用者和非使用对照的初步研究。该项目旨在证明，微结构的白色物质的完整性可能会受到损害，大麻依赖，这可能会影响神经认知功能。如果得到证实，这些发现可以增加我们对这种疾病的潜在病理生理机制的理解，并为这种疾病的潜在治疗方法的发展提供信息。我们假设，较重和长期使用大麻将有神经认知缺陷相比，不使用的主题，这些缺陷将与增加白色物质的微结构与MRI观察。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a pilot study of (N=30) young adult (18-24) marijuana users and non-using controls. This project seeks to demonstrate that microstructural white matter integrity may be compromised in marijuana dependence and that this may affect neurocognitive functioning. If confirmed, these findings could increase our understanding of the underlying pathophysiological mechanisms of this disorder and inform the development of potential treatments for the disorder. We hypothesize that heavier and longer term users of marijuana will have neurocognitive deficits compared to non-using subjects and these deficits will be correlated with increased white matter microstructure observed with MRI.