STUDY OF ACID REFLUX AND ASTHMA

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。我们提出了一项为期六个月的随机临床试验，对已经在接受吸入皮质类固醇治疗的症状性哮喘患者与非活性的类似安慰剂的患者进行为期六个月的临床试验。总共有25名哮喘受试者(全国400名)将在明尼苏达州接受大约6个月的治疗。在这项研究中，主要的结果衡量标准是治疗期间哮喘加重的频率。这项研究是美国肺脏协会哮喘临床研究中心正在进行的合作的一部分，该中心是一个由美国各地的19个研究中心组成的小组。每个研究中心都有多个合作地点，在这些地点将根据这一协议观察受试者。我们网站的所有研究访问都将在综合临床研究中心进行。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We propose a randomized clinical trial of six-month proton-pump inhibitor therapy for patients with symptomatic asthma who are already being treated with inhaled corticosteroids vs inactive similar-appearing placebo. A total of 25 asthmatic subjects (400 nationwide) will be treated in Minnesota for approximately six months. The primary outcome measure in this study is frequency of asthma exacerbations during the treatment interval. This study is part of a collaboration being conducted by the American Lung Association Asthma Clinical Research Centers, a group of 19 study centers throughout the U.S. Each study center has multiple collaborating sites at which subjects will be seen under this protocol. All study visits for our site will take place at the General Clinical Research Center.