CLINICAL TRIAL: STUDY OF ACID REFLUX AND ASTHMA

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，不一定是研究者的机构。 我们提出了一个随机临床试验，质子泵抑制剂治疗6个月的症状性哮喘患者谁已经被吸入皮质类固醇与非活性相似的安慰剂治疗。共有25名哮喘受试者（全国400名）将在明尼苏达州接受约6个月的治疗。 本研究的主要结局指标是治疗期间哮喘急性发作的频率。本研究是美国肺协会哮喘临床研究中心合作的一部分，该中心由美国19个研究中心组成。每个研究中心都有多个合作中心，受试者将在这些中心接受本方案的治疗。 我们研究中心的所有研究访视将在综合临床研究中心进行。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We propose a randomized clinical trial of six-month proton-pump inhibitor therapy for patients with symptomatic asthma who are already being treated with inhaled corticosteroids vs inactive similar-appearing placebo. A total of 25 asthmatic subjects (400 nationwide) will be treated in Minnesota for approximately six months. The primary outcome measure in this study is frequency of asthma exacerbations during the treatment interval. This study is part of a collaboration being conducted by the American Lung Association Asthma Clinical Research Centers, a group of 19 study centers throughout the U.S. Each study center has multiple collaborating sites at which subjects will be seen under this protocol. All study visits for our site will take place at the General Clinical Research Center.