LEUKOCYTE ADHESION IN ALLERGIC INFLAMMATION/SEROTONIN (5-HT) AND 5-HT2A IN ALLER

过敏性炎症中的白细胞粘附/过敏症中的血清素 (5-HT) 和 5-HT2A

• 批准号: 7951770
• 负责人: Malcolm Nolan Blumenthal
• 金额: $ 0.04万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951770
• 关键词: Adhesions; Allergic; Blood Vessels; Cell Adhesion Molecules; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; HTR2A gene; Inflammation; Inflammatory; Institution; Leukocytes; Lung; Mediating; Mediator of activation protein; Play; Research; Research Personnel; Resources; Role; Serotonin; Site; Source; United States National Institutes of Health; chemokine; cytokine; eosinophil

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Studies have revealed that eosinophils roll, adhere and transmigrate from blood vessels to various sites of allergic inflammation, including the lungs, and suggest that adhesion molecules, cytokines as well as chemokines may play a critical role in the inflammatory cascade leading to sequestration of circulating eosinophils. The purpose of this study is to further understand the role and importance of these mediators in eosinophil-mediated allergic inflammation.

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