CATHETER-RELATED INFECTIONS IN PEDIATRIC DIALYSIS PATIENTS: POTENTIAL ROLE OF

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。患有终末期肾病(ESRD)的儿童和青少年需要通过经皮途径设备进行透析，容易发生严重的细菌感染，包括导管相关性败血症。我们对导致透析患者发生导管相关感染的宿主因素的理解存在相当大的差距。ESRD患者的单核/巨噬细胞功能紊乱已有文献记载。该项目将测试以下假设：血浆趋化因子水平和细胞相关趋化因子受体的异常会导致巨噬细胞功能减弱，增加发生严重细菌感染(如导管相关性败血症)的风险，对治疗的反应减弱，以及透析患者的反复感染。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Children and adolescents with end stage renal disease (ESRD) who require dialysis through percutaneous access devices are susceptible to serious bacterial infections including catheter-related sepsis. There are considerable gaps in our understanding of the host factors that predispose patients on dialysis to develop catheter-related infections. Disturbances in monocyte/macrophage function have been documented in patients with ESRD. This project will test the hypothesis that abnormalities in plasma chemokine levels and cell-associated chemokine receptors result in diminished macrophage function, heightened risk of developing serious bacterial infections such as catheter-related sepsis, impaired response to treatment, and recurrent infection in pediatric patients on dialysis.