CATHETER-RELATED INFECTIONS IN PEDIATRIC DIALYSIS PATIENTS: POTENTIAL ROLE OF

小儿透析患者导管相关感染：潜在作用

• 批准号: 7377123
• 负责人: HOWARD TRACHTMAN
• 金额: $ 0.08万
• 依托单位: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7377123
• 关键词: CATHETER; RELATED; INFECTIONS; PEDIATRIC; DIALYSIS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Children and adolescents with end stage renal disease (ESRD) who require dialysis through percutaneous access devices are susceptible to serious bacterial infections including catheter-related sepsis. There are considerable gaps in our understanding of the host factors that predispose patients on dialysis to develop catheter-related infections. Disturbances in monocyte/macrophage function have been documented in patients with ESRD. This project will test the hypothesis that abnormalities in plasma chemokine levels and cell-associated chemokine receptors result in diminished macrophage function, heightened risk of developing serious bacterial infections such as catheter-related sepsis, impaired response to treatment, and recurrent infection in pediatric patients on dialysis.

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。患有终末期肾病（ESRD）的儿童和青少年需要通过经皮透析装置进行透析，容易发生严重的细菌感染，包括导管相关性败血症。我们对易使透析患者发生导管相关感染的宿主因素的理解存在相当大的差距。ESRD患者单核细胞/巨噬细胞功能紊乱已被证实。该项目将测试血浆趋化因子水平和细胞相关趋化因子受体异常导致巨噬细胞功能下降，发生严重细菌感染（如导管相关性败血症）的风险增加，治疗反应受损以及透析儿科患者复发感染的假设。