CLINICAL TRIAL: A PILOT STUDY OF MYCOPHENOLATE MOFETIL IN CONGENITAL UROPATHIES

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Emerging evidence suggests that inflammatory mediators that infiltrate the kidney in children with congenital uropathies contribute to the progressive decline in kidney function that is observed in these patients. The strategy of using immunosuppressive therapy to protect against progressive, primary non-immunological forms of kidney disease has never been tested in clinical practice involving children or adult patients. This study is designed to test the hypothesis that administration of mycophenolate mofetil to children with congenital uropathies will be safe and well tolorated and may prevent the progressive decline of kidney function in patients with congenital uropathies.