CLINICAL TRIAL: A PILOT STUDY OF MYCOPHENOLATE MOFETIL IN CONGENITAL UROPATHIES
临床试验:吗替麦酚酯治疗先天性尿路病的试点研究
基本信息
- 批准号:7719241
- 负责人:
- 金额:$ 0.28万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2008
- 资助国家:美国
- 起止时间:2008-04-22 至 2009-03-31
- 项目状态:已结题
- 来源:
- 关键词:AdultChildClinicalClinical TrialsComputer Retrieval of Information on Scientific Projects DatabaseFundingGrantInflammatoryInstitutionKidneyKidney DiseasesMediator of activation proteinPatientsPilot ProjectsRenal functionResearchResearch PersonnelResourcesSourceTestingTherapeutic immunosuppressionUnited States National Institutes of Healthdesignmycophenolate mofetilprevent
项目摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
Emerging evidence suggests that inflammatory mediators that infiltrate the kidney in children with congenital uropathies contribute to the progressive decline in kidney function that is observed in these patients. The strategy of using immunosuppressive therapy to protect against progressive, primary non-immunological forms of kidney disease has never been tested in clinical practice involving children or adult patients. This study is designed to test the hypothesis that administration of mycophenolate mofetil to children with congenital uropathies will be safe and well tolorated and may prevent the progressive decline of kidney function in patients with congenital uropathies.
这个子项目是许多研究子项目中的一个
由NIH/NCRR资助的中心赠款提供的资源。子项目和
研究者(PI)可能从另一个NIH来源获得了主要资金,
因此可以在其他CRISP条目中表示。所列机构为
研究中心,而研究中心不一定是研究者所在的机构。
新出现的证据表明,炎症介质浸润肾脏的儿童先天性尿路病有助于肾功能的进行性下降,在这些患者中观察到。 使用免疫抑制治疗来预防进行性原发性非免疫性肾病的策略从未在涉及儿童或成人患者的临床实践中进行过测试。 本研究旨在验证以下假设:先天性尿路病儿童接受吗替麦考酚酯给药安全、耐受性良好,并可预防先天性尿路病患者肾功能进行性下降。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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HOWARD TRACHTMAN其他文献
HOWARD TRACHTMAN的其他文献
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{{ truncateString('HOWARD TRACHTMAN', 18)}}的其他基金
Developmental Origins of Kidney Function in Early Life and Environmental Risks
生命早期肾功能的发育起源和环境风险
- 批准号:
10064557 - 财政年份:2020
- 资助金额:
$ 0.28万 - 项目类别:
Environmental Oxidant Stressors in Pediatric Chronic Kidney Disease - Resubmissio
小儿慢性肾脏病中的环境氧化应激 - Resubmissio
- 批准号:
8911312 - 财政年份:2014
- 资助金额:
$ 0.28万 - 项目类别:
CLINICAL TRIAL: TREATMENT WITH (F6-3019) FOR FOCAL GLOMERULOSCLEROSIS
临床试验:(F6-3019)治疗局灶性肾小球硬化症
- 批准号:
7951946 - 财政年份:2009
- 资助金额:
$ 0.28万 - 项目类别:
TREATMENT WITH HUMAN MONOCLONAL ANTIBODY TO CONNECTIVE TISSUE GROWTH FACTOR (FG-
结缔组织生长因子 (FG-) 人单克隆抗体治疗
- 批准号:
7719299 - 财政年份:2008
- 资助金额:
$ 0.28万 - 项目类别:
CATHETER-RELATED INFECTIONS IN PEDIATRIC DIALYSIS PATIENTS: POTENTIAL ROLE OF
小儿透析患者导管相关感染:潜在作用
- 批准号:
7719251 - 财政年份:2008
- 资助金额:
$ 0.28万 - 项目类别:
CLINICAL TRIAL: NOVEL THERAPY FOR RESISTANT FOCAL SEGMENTAL GLOMERULOSCLEROSIS
临床试验:治疗难治性局灶节段性肾小球硬化症的新疗法
- 批准号:
7719255 - 财政年份:2008
- 资助金额:
$ 0.28万 - 项目类别:
NOVEL THERAPY FOR RESISTANT FOCAL SEGMENTAL GLOMERULOSCLEROSIS
抵抗性局灶节段性肾小球硬化症的新疗法
- 批准号:
7608248 - 财政年份:2007
- 资助金额:
$ 0.28万 - 项目类别:
A PILOT STUDY OF MYCOPHENOLATE MOFETIL IN CONGENITAL UROPATHIES
吗替麦酚酯治疗先天性尿路病的初步研究
- 批准号:
7608227 - 财政年份:2007
- 资助金额:
$ 0.28万 - 项目类别:
NOVEL THERAPY FOR RESISTANT FOCAL SEGMENTAL GLOMERULOSCLEROSIS (FSGS)
抵抗性局灶节段性肾小球硬化症 (FSGS) 的新疗法
- 批准号:
7377133 - 财政年份:2006
- 资助金额:
$ 0.28万 - 项目类别:
CATHETER-RELATED INFECTIONS IN PEDIATRIC DIALYSIS PATIENTS: POTENTIAL ROLE OF
小儿透析患者导管相关感染:潜在作用
- 批准号:
7377123 - 财政年份:2006
- 资助金额:
$ 0.28万 - 项目类别:
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