CATHETER-RELATED INFECTIONS IN PEDIATRIC DIALYSIS PATIENTS: POTENTIAL ROLE OF

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Children and adolescents with end stage renal disease (ESRD) who require dialysis through percutaneous access devices are susceptible to serious bacterial infections including catheter-related sepsis. There are considerable gaps in our understanding of the host factors that predispose patients on dialysis to develop catheter-related infections. Disturbances in monocyte/macrophage function have been documented in patients with ESRD. This project will test the hypothesis that abnormalities in plasma chemokine levels and cell-associated chemokine receptors result in diminished macrophage function, heightened risk of developing serious bacterial infections such as catheter-related sepsis, impaired response to treatment, and recurrent infection in pediatric patients on dialysis.