CATHETER-RELATED INFECTIONS IN PEDIATRIC DIALYSIS PATIENTS: POTENTIAL ROLE OF

小儿透析患者导管相关感染：潜在作用

• 批准号: 7719251
• 负责人: HOWARD TRACHTMAN
• 金额: $ 0.55万
• 依托单位: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-22 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719251
• 关键词: Adolescent; Bacterial Infections; Catheters; Cells; Child; Childhood; Computer Retrieval of Information on Scientific Projects Database; Devices; Dialysis patients; Dialysis procedure; End stage renal failure; Funding; Grant; Infection; Institution; Integration Host Factors; Patients; Physical Dialysis; Plasma; Recurrence; Research; Research Personnel; Resources; Risk; Role; Sepsis; Source; Testing; United States National Institutes of Health; catheter related infection; chemokine; chemokine receptor; macrophage; monocyte; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Children and adolescents with end stage renal disease (ESRD) who require dialysis through percutaneous access devices are susceptible to serious bacterial infections including catheter-related sepsis. There are considerable gaps in our understanding of the host factors that predispose patients on dialysis to develop catheter-related infections. Disturbances in monocyte/macrophage function have been documented in patients with ESRD. This project will test the hypothesis that abnormalities in plasma chemokine levels and cell-associated chemokine receptors result in diminished macrophage function, heightened risk of developing serious bacterial infections such as catheter-related sepsis, impaired response to treatment, and recurrent infection in pediatric patients on dialysis.

这个子项目是众多研究子项目之一