MORBID OBESITY & WEIGHT LOSS ON REPRODUCTIVE FUNCTION: BARIATRIC SURGERY MODEL

病态肥胖

• 批准号: 7378503
• 负责人: ROBERT COONEY
• 金额: $ 1.16万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7378503
• 关键词: MORBID; OBESITY; WEIGHT; LOSS; REPRODUCTIVE

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this study is to investigate the effects of morbid obesity and weight loss on human reproductive function in patients undergoing gastric bypass surgery. Hypotheses: 1. Morbid obesity leads to reproductive abnormalities in men and women. 2. Bariatric surgery alters GI hormone expression producing immediate changes in the hypothalamic-pituitary-gonadal axis. 3. Fat mass reduction causes changes in adipokine levels leading to improved reproductive function. The primary outcome measurement for men is monthly testosterone AUC and for women pregnanediol 3-glucuronide AUC. This is an observational pilot study involving 20 obese subjects, 10 men and 10 women, over two years.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。这项研究的目的是研究病态肥胖症和体重减轻对接受胃搭桥手术的患者人类生殖功能的影响。假设：1。病态肥胖导致男性和女人的生殖异常。 2。减肥手术改变了胃肠伤激素的表达，从而在下丘脑 - 垂体 - 基达轴上立即改变。 3。脂肪量减少会导致脂肪因子水平的变化，从而改善生殖功能。男性的主要结局测量是每月睾丸激素AUC和女性怀孕3-葡萄糖醛酸AUC。这是一项观察性的试点研究，涉及两年的20名肥胖受试者，10名男性和10名女性。