AGE AND CONTROL OF HUMAN SKIN BLOOD FLOW:: SKIN SYMPATHETIC NERVE ACTIVITY

人类皮肤血流的年龄和控制:: 皮肤交感神经活动

• 批准号: 7378532
• 负责人: W. LARRY KENNEY
• 金额: $ 1.2万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7378532
• 关键词: AGE; CONTROL; HUMAN; SKIN; BLOOD

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Research has shown that older people are less able to constrict cutaneous blood vessels in the cold. Since vasoconstriction increases the insulative capacity of the skin, impairment of this response causes increased heat loss in the cold and can make older people more susceptible to hypothermia. The primary site(s) of the age-related alteration in VC is unknown, but evidence points to efferent pathways (postganglionic sympathetic nerve activity, differential neurotransmitter effects, cutaneous vascular response) rather than primary age differences in hypothalamic integration. The specific aim of the present application examines a possible and plausible site in the efferent control pathway at which the age-related attenuation of reflex VC may occur. The proposed technique, quantitative skin microneurography, represents a state-of-the-art in vivo experimental approach. Until recently, this technique, or recent refinements thereof, were not available to test the stated hypotheses in human skin in vivo.

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。研究表明，老年人在寒冷中收缩皮肤血管的能力较差。由于血管收缩增加了皮肤的隔热能力，这种反应的损害会导致寒冷中热量损失的增加，并可能使老年人更容易受到体温过低的影响。Vc中年龄相关性改变的原发部位(S)尚不清楚，但有证据表明，下丘脑整合的传出通路(节后交感神经活动、差异神经递质效应、皮肤血管反应)而不是原发年龄差异。本申请的具体目的是检查传出控制通路中可能出现与年龄相关的反射性VC衰减的位置。这项拟议的技术，定量皮肤显微神经学，代表了一种最先进的活体实验方法。直到最近，这项技术，或其最近的改进，还不能在活体人体皮肤上测试所述的假设。