AGE AND CONTROL OF HUMAN SKIN BLOOD FLOW:: SKIN SYMPATHETIC NERVE ACTIVITY

人类皮肤血流的年龄和控制:: 皮肤交感神经活动

• 批准号: 7378532
• 负责人: W. LARRY KENNEY
• 金额: $ 1.2万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7378532
• 关键词: AGE; CONTROL; HUMAN; SKIN; BLOOD

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Research has shown that older people are less able to constrict cutaneous blood vessels in the cold. Since vasoconstriction increases the insulative capacity of the skin, impairment of this response causes increased heat loss in the cold and can make older people more susceptible to hypothermia. The primary site(s) of the age-related alteration in VC is unknown, but evidence points to efferent pathways (postganglionic sympathetic nerve activity, differential neurotransmitter effects, cutaneous vascular response) rather than primary age differences in hypothalamic integration. The specific aim of the present application examines a possible and plausible site in the efferent control pathway at which the age-related attenuation of reflex VC may occur. The proposed technique, quantitative skin microneurography, represents a state-of-the-art in vivo experimental approach. Until recently, this technique, or recent refinements thereof, were not available to test the stated hypotheses in human skin in vivo.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中得到体现。列出的机构是中心的机构，不一定是研究者的机构。研究表明，老年人在寒冷时收缩皮肤血管的能力较差。由于血管收缩会增加皮肤的隔热能力，因此这种反应的损害会导致寒冷时热量损失增加，并使老年人更容易出现体温过低的情况。 VC 与年龄相关的改变的主要部位尚不清楚，但有证据表明传出通路（节后交感神经活动、神经递质差异效应、皮肤血管反应）而不是下丘脑整合的主要年龄差异。本申请的具体目的是检查传出控制通路中可能发生年龄相关的反射VC减弱的可能且合理的位点。所提出的技术，定量皮肤显微神经造影，代表了最先进的体内实验方法。直到最近，这种技术或其最近的改进还无法在人体皮肤体内测试所述假设。