DETERMINANTS OF PHYSICAL ACTIVITY IN PERIPHERAL ARTERIAL DISEASE

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。在看似健康的成年人中，每天低水平的体力活动与心血管疾病发病率和死亡率的高风险相关。在周围动脉疾病(PAD)患者中，久坐生活的不良预后可能会进一步加剧，他们的死亡率已经是没有PAD患者的11倍。因此，日常体力活动减少和PAD的存在可能协同作用，将PAD患者置于后续心血管事件的最高风险组之一。由于间歇性跛行相关的活动受限，PAD是发病率的主要原因。间歇性跛行是指小腿、大腿或臀部肌肉群在行走过程中出现的缺血性肌肉疼痛，当步速超过外周循环的能力时，就会充分灌流活跃的下肢肌肉系统。由于步行是老年人进行的主要体力活动之一，因此PAD受试者采取久坐不动的生活方式并通常聚集在体力活动谱的极低端也就不足为奇了。事实上，测量垫的严重程度，如在跑步机测试中获得的跛行距离和踝臂指数(ABI)与日常体力活动有关。此外，与目前不吸烟的人相比，目前吸烟的PAD患者采取了更久坐的生活方式。这些发现表明，下肢血管受限的程度和吸烟是PAD受试者日常身体活动的关键决定因素。目的：确定外周动脉疾病(PAD)患者日常体力活动的决定因素。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Low levels of daily physical activity are associated with heightened risk of cardiovascular morbidity and mortality in apparently healthy adults. The poor prognosis of sedentary living may be compounded even further in peripheral arterial disease (PAD) subjects, who already have an 11-fold higher mortality rate than individuals free of PAD. Consequently, the combination of decreased daily physical activity and the presence of PAD may act synergistically to place PAD subjects in one of the highest at-risk groups for subsequent cardiovascular events. PAD is a leading cause of morbidity due to ambulatory limitations associated with intermittent claudication. Intermittent claudication is ischemic muscular pain that occurs in the calf, thigh, or buttock muscle groups during ambulation when the pace exceeds the capacity of the peripheral circulation to adequately perfuse the active lower extremity musculature. Because ambulation is one of the primary physical activities performed by the elderly, it is not surprising that PAD subjects adopt a sedentary lifestyle and typically cluster around the extreme low end of the physical activity spectrum. Indeed, measures of PAD severity, such as claudication distances obtained during a treadmill test and the ankle/brachial index (ABI) are related to daily physical activity. Additionally, PAD subjects who currently smoke adopt a more sedentary lifestyle than current non-smokers. These findings suggest that the extent of vascular limitations in the lower extremities and cigarette smoking are key determinants in daily physical activity in PAD subjects. Purpose: to identify the determinants of daily physical activity in subjects with peripheral arterial disease (PAD).