EXERCISE FOR ELDERLY PERIPHERAL REVASCULARIZED PATIENTS

老年末梢血运重建患者的锻炼

• 批准号: 7608085
• 负责人: ANDREW K GARDNER
• 金额: $ 7.77万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7608085
• 关键词: Address; Adjuvant; Aerobic Exercise; Affect; Arterial Occlusive Diseases; Blood Circulation; Cardiopulmonary; Computer Retrieval of Information on Scientific Projects Database; Control Groups; Controlled Clinical Trials; Daily; Elderly; Exercise; Functional disorder; Funding; Grant; Institution; Ischemia; Life; Limb structure; Patients; Peripheral; Physical activity; Quality of life; Randomized; Rehabilitation therapy; Research; Research Personnel; Residual state; Resources; Secondary to; Source; Time; Training; United States National Institutes of Health; Walking; Week; claudication; functional improvement; functional outcomes; functional status; health related quality of life; hemodynamics; improved; programs; revascularization surgery; trial comparing

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Peripheral arterial occlusive disease (PAOD) patients with critical limb-threatening ischemia have improved peripheral circulation following infrainguinal revascularization. Despite this hemodynamic benefit, little change in functional status occurs, and many patients have residual ambulatory dysfunction. The lack of functional improvement in revascularized patients may be due to extreme physical deconditioning secondary to their pre-existing critical limb-threatening ischemia. Therefore, we hypothesize that a program of aerobic exercise training is necessary to optimize ambulation, free-living daily physical activity, and health-related quality of life through the mechanisms of improved walking economy, cardiopulmonary function, and further gains in peripheral circulation. This randomized controlled clinical trial comparing an exercise group undergoing a program of graded treadmill walking, and a delayed-entry non-exercise control group will address the following two aims: (1) to determine whether a 3-month exercise rehabilitation program will improve claudication distances, free-living daily physical activity, and health-related quality of life of older, revascularized patients with PAOD, and (2) to determine whether the primary mechanisms by which exercise rehabilitation affects the above functional outcomes are through alterations in walking economy, peripheral circulation, and cardiopulmonary function. Eighty revascularized PAOD patients will be randomized and complete either the exercise group (N=40) or the delayed-entry non-exercise group (N=40). The 3-month exercise program will consist of graded treadmill walking 3 times per week with progressive increments in exercise duration from 15 to 40 minutes, and progressive increments in exercise intensity from 50 to 80% of exercise capacity. We believe this study will demonstrate that exercise rehabilitation is an important adjuvant to revascularization surgery to achieve clinically meaningful gains in ambulation, free-living daily physical activity, and quality of life in PAOD patients with critical limb-threatening ischemia.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 周围动脉闭塞性疾病（PAOD）患者在腹股沟下血管重建后，其严重的肢体缺血改善了外周循环。 尽管有这种血流动力学益处，但功能状态几乎没有变化，许多患者仍有残余的行走功能障碍。 血运重建患者的功能缺乏改善可能是由于继发于其预先存在的严重肢体威胁性缺血的极端身体失调。 因此，我们假设，有氧运动训练计划是必要的，以优化amphibia，自由生活的日常体力活动，并通过改善步行经济，心肺功能，并进一步获得外周循环的机制与健康相关的生活质量。 这项随机对照临床试验比较了接受分级跑步机步行计划的运动组和延迟进入的非运动对照组，将解决以下两个目标：（1）确定3个月的运动康复计划是否会改善老年PAOD血运重建患者的跛行距离、自由生活日常体力活动和健康相关生活质量，以及（2）确定运动康复影响上述功能结果的主要机制是否是通过改变步行经济性、外周循环和心肺功能。 80例血运重建PAOD患者将被随机分配并完成运动组（N=40）或延迟入组非运动组（N=40）。 3个月的运动计划将包括每周3次分级跑步机步行，运动持续时间从15分钟逐渐增加到40分钟，运动强度从运动能力的50%逐渐增加到80%。 我们相信这项研究将证明，运动康复是一个重要的辅助血管重建手术，以实现临床有意义的增益在amphibia，自由生活的日常体力活动，和生活质量的PAOD患者严重的肢体威胁缺血。