INSULIN SENSITIVITY AND BODY FAT IN CHILDREN

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。本研究的目的是研究健康的美洲原住民和高加索儿童胰岛素敏感性与体脂量和分布（中枢脂肪和外周脂肪）之间的功能关系。假设：主要的假设是：1)在胰岛素敏感性和印第安人血液量（印第安人血液的百分比）之间存在反比关系，2)在任何给定的身体质量指数（BMI）下，印第安人儿童将比高加索儿童有更多的总脂肪量和更多的胰岛素抵抗。研究对象：采用非匹配研究设计的4个研究小组（12 - 17岁），采用美国原住民和高加索儿童（12 - 17岁），每组8人，每组8人作为研究对象（N=32）。方法：采用频繁取样胰岛素葡萄糖耐量试验（FSIGTT）评估胰岛素敏感性，同时用DEXA测量全身脂肪和分布。意义：这些结果将是重要的，因为它们将增强我们对潜在的代谢和生理特征的理解，这些特征有助于观察到儿童2型糖尿病发病率的种族和民族差异，这将导致创新的，文化特异性的预防和治疗策略。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objective of this proposal is to investigate the functional relationships between insulin sensitivity with body fat mass and distribution (central vs. peripheral fat) in healthy Native American and Caucasian children. Hypotheses: The central hypotheses are that: 1) there is an inverse relationship between insulin sensitivity and Native American blood quantum (percentage of Native American blood), and 2) at any given body mass index (BMI), Native American children will, have greater amounts of total body fat and be more insulin-resistant than Caucasian children. Subjects: Four study groups utilizing a non-matched study design of Native Americans and Caucasian children (12 - 17 years old) divided by males and females using 8 per group will serve as study subjects (total N=32). Methods: Insulin sensitivity will be assessed utilizing the frequently sampled insulin glucose tolerance test (FSIGTT) while total body fat and distribution will be measured with DEXA. Significance: The results will be significant, because they will enhance our understanding of the underlying metabolic and physiologic characteristics that contribute to observed racial and ethnic differences in the incidence of type-2 diabetes in children, which made lead to innovative, culturally-specific strategies toward prevention and treatment.