INSULIN SENSITIVITY AND BODY FAT IN CHILDREN

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项建议的目的是调查健康的美洲原住民和高加索儿童的胰岛素敏感性与身体脂肪质量和分布(中心脂肪与外围脂肪)之间的功能关系。假设：中心假设是：1)胰岛素敏感性与美洲原住民血液量(美洲原住民血液的百分比)成反比，2)在任何给定的体重指数(BMI)下，美国原住民儿童的体脂总量都会比高加索儿童多，对胰岛素的抵抗力也更强。研究对象：四个研究小组采用非配对研究设计，将美洲原住民和高加索儿童(12-17岁)除以男性和女性，每组8人作为研究对象(总计N=32)。方法：用频繁采样胰岛素葡萄糖耐量试验(FSIGTT)评估胰岛素敏感性，用DEXA测量总体脂及其分布。意义：结果将是重要的，因为它们将增强我们对潜在的代谢和生理特征的理解，这些特征有助于观察到儿童2型糖尿病发病率的种族和民族差异，这导致了针对特定文化的创新预防和治疗策略。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objective of this proposal is to investigate the functional relationships between insulin sensitivity with body fat mass and distribution (central vs. peripheral fat) in healthy Native American and Caucasian children. Hypotheses: The central hypotheses are that: 1) there is an inverse relationship between insulin sensitivity and Native American blood quantum (percentage of Native American blood), and 2) at any given body mass index (BMI), Native American children will, have greater amounts of total body fat and be more insulin-resistant than Caucasian children. Subjects: Four study groups utilizing a non-matched study design of Native Americans and Caucasian children (12 - 17 years old) divided by males and females using 8 per group will serve as study subjects (total N=32). Methods: Insulin sensitivity will be assessed utilizing the frequently sampled insulin glucose tolerance test (FSIGTT) while total body fat and distribution will be measured with DEXA. Significance: The results will be significant, because they will enhance our understanding of the underlying metabolic and physiologic characteristics that contribute to observed racial and ethnic differences in the incidence of type-2 diabetes in children, which made lead to innovative, culturally-specific strategies toward prevention and treatment.