CVD INFLUENZA 6000

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。流感是由几种相关病毒引起的一种常见感染。它每年在美国造成20,000-40,000人死亡。当一种新的流感病毒感染人类时，这种感染可以迅速在世界各地传播。这种在全球范围内的传播称为大流行。在过去的100年里，发生了几次大流行。这些大流行导致大量人感染和死亡。1918年，近4000万人死于流感大流行。一些新的人类流感病毒来自禽流感病毒(也称为禽流感)。最近，一些禽流感病毒株在亚洲感染了人，并导致多人死亡。其中一种流感病毒被称为A/H5N1。有人担心这种新的毒株可能会导致大流行。疫苗可以预防感染和疾病。疫苗的工作原理是使身体产生一种名为抗体的蛋白质来对抗感染。有时需要一剂以上的疫苗，这样身体才能产生足够的抗体来对抗感染。已经开发出了预防感染“常规”流感病毒的疫苗。这些流感疫苗可以预防流感及其引起的健康问题。它们是由被杀死的流感病毒的一部分制成的，作为手臂上的一剂“针”。我们正在进行这项研究，使用的是针对禽流感病毒A/H5N1的灭活流感病毒疫苗。这种疫苗被认为是研究中的疫苗。它从未在人体上进行过试验。这种疫苗的制作方法与每年流感季节前给人接种的“常规”流感疫苗相同。在这项研究中，我们试图找出这种疫苗需要多大的强度才能产生保护性水平的禽流感抗体，这将帮助我们决定未来需要使用的正确剂量。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Influenza (the flu) is a common infection caused by several related viruses. It is responsible for 20,000-40,000 deaths each year in the United States. When a new strain of flu infects people, the infection can spread around the world quickly. This worldwide spread is called a pandemic. Several pandemics have occurred in the last 100 years. These pandemics caused infection and death in a high number of people. In 1918, nearly 40 million people died in a flu pandemic. Some of the new human flu viruses come from bird flu viruses (also known as avian flu). Recently, some strains of bird flu viruses have infected people in Asia and caused a number of deaths. One of these flu strains is called A/H5N1. There is concern this new strain could cause a pandemic. Vaccines can prevent infection and disease. Vaccines work by causing the body to make proteins called antibodies that fight infection. Sometimes more than 1 dose of vaccine is needed so that the body will make enough antibodies to fight infection. Vaccines have already been developed to prevent infection with "regular" flu viruses. These flu vaccines protect against flu and the health problems it causes. They are made from parts of killed flu virus and are given as a "shot" in the arm. We are conducting this research study using a killed flu virus vaccine against the bird flu virus, A/H5N1. This vaccine is considered investigational. It has never been tested in humans. This vaccine was made the same way as "regular" flu vaccine that is given to people every year before flu season. In this study, we are trying to find out what strength of this vaccine is needed to produce protective levels of "bird flu" antibodies, which will help us decide the right dose for use in the future, if it is needed.