HEART FAILURE PATIENT EXERCISE TRAINING

心力衰竭患者运动训练

• 批准号: 7376970
• 负责人: STEPHEN GOTTLIEB
• 金额: $ 0.59万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376970
• 关键词: HEART; FAILURE; PATIENT; EXERCISE; TRAINING

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Heart Failure and A Controlled Trial Investigating Outcomes of Exercise TraiNing (HF-ACTION) is a multicenter, international, randomized trial that addresses the primary hypothesis that patients with left ventricular (LV) systolic dysfunction and New York Heart Association (NYHA) class II-IV symptoms who are given exercise training in addition to standard care will have a 20% lower rate of death and hospitalization over two years than patients who receive usual care alone. Important secondary endpoints include exercise testing parameters, economics, quality of life, and depression. Over three years, regional centers in the United States and Canada and their satellite centers will recruit 3,000 consenting patients with heart failure (HF), LV ejection fraction (EF) 35%, and NYHA class II-IV. Once identified and screened, these patients will be randomized in a 1:1 fashion to receive usual care or usual care plus exercise training. Patients in the intervention arm will undergo 36 supervised exercise training sessions before initiating a home exercise training regimen that will be supplemented with occasional supervised review training sessions. All patients will perform gas exchange exercise tests at baseline, 3 months, 12 months, and 24 months of follow-up. All randomized patients will receive follow-up clinic and telephone calls at pre-specified times. Registries of clinical information will be maintained on eligible patients who decline trial entry. The results of the HF-ACTION trial will have a significant impact on the health and quality of life of millions of patients who now suffer from HF.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。心力衰竭与运动训练结果的对照研究（HF-ACTION）是一个多中心，国际，一项随机试验，主要假设左心室（LV）收缩功能障碍和纽约心脏协会（NYHA）II-IV级症状的患者在标准治疗的基础上接受运动训练，两年内的死亡率和住院率低于仅接受常规治疗的患者。重要的次要终点包括运动试验参数、经济学、生活质量和抑郁症。在三年内，美国和加拿大的区域中心及其卫星中心将招募3，000名同意的心力衰竭（HF）患者，LV射血分数（EF）35%，NYHA II-IV级。一旦确定和筛选，这些患者将以1：1的比例随机接受常规治疗或常规治疗加运动训练。干预组的患者将在开始家庭运动训练方案之前接受36次监督运动训练，并补充偶尔的监督回顾训练。所有患者将在基线、3个月、12个月和24个月随访时进行气体交换运动试验。所有随机化患者将在预先规定的时间接受门诊随访和电话随访。将保留拒绝参加试验的合格患者的临床信息登记。HF-ACTION试验的结果将对目前患有HF的数百万患者的健康和生活质量产生重大影响。