HIV SPECIFIC IMMUNE RESPONSES AND DISEASE PROGRESSION IN PEDIATRIC HIV-1 INFECTI

儿科 HIV-1 感染者的 HIV 特异性免疫反应和疾病进展

• 批准号: 7376206
• 负责人: Hans M Spiegel
• 金额: $ 0.14万
• 依托单位: CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376206
• 关键词: HIV; SPECIFIC; IMMUNE; RESPONSES; DISEASE

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Children and adolescents with HIV infection display great variability in their clinical course and rate of progression to AIDS. The specific aims of this study are 1) to characterize the magnitude, breadth, and epitope specificity of HIV-specific CTL and T-helper responses in a cohort of HIV-infected pediatric subjects (ages birth to 21 years); and 2) to use new assays to gain a better understanding of the determinants of innate immunity (NK cells, NKT cells) and dendritic cells/monocytes in the control of HIV viremia in pediatric subjects. One hypothesis of this study is that in pediatric subjects who are not receiving antiretroviral therapy or who are viremic on highly active antiretroviral therapy (HAART), but are asymptomatic, correlates of effective immune control of HIV-1 can be identified. The second hypothesis is that differences in innate immune responses of asymptomatic pediatric subjects with control viremia as compared to pediatric subjects with high viral loads and clinical progression, can be identified by longitudinal comparison of functional and phenotypic markers of NK cells, NKT cells and dendritic cells/monocytes.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。患有艾滋病毒感染的儿童和青少年在临床过程中表现出很大的差异和艾滋病的发展速度。这项研究的具体目的是1）表征HIV特异性CTL和T-Helper反应的大小，广度和表位特异性在一组HIV感染的儿科受试者中（年龄21岁）； 2）使用新测定方法可以更好地了解先天免疫（NK细胞，NKT细胞）和树突状细胞/单核细胞的决定因素，以控制儿科受试者的HIV病毒血症。这项研究的一个假设是，在未接受抗逆转录病毒疗法或在高度活跃的抗逆转录病毒治疗（HAART）中病毒的小儿受试者中，可以鉴定出有效的HIV-1免疫控制的相关性。第二个假设是，与具有高病毒载荷和临床进展的儿科受试者相比，无症状的儿科受试者先天免疫反应的差异可以通过对NK细胞，NKT细胞和树突状细胞/单粒细胞/单粒细胞/单粒细胞/单粒细胞/单粒细胞的功能和表型标记的纵向比较来鉴定。