ACTG 219C: PEDIATRIC LATE OUTCOME PROTOCOL, VERSION 30 HIV/AIDS

ACTG 219C：儿科晚期结果方案，版本 30 HIV/AIDS

• 批准号: 7717147
• 负责人: Hans M Spiegel
• 金额: $ 5.65万
• 依托单位: CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7717147
• 关键词: AIDS clinical trial group; AIDS/HIV problem; Adolescent; Anti-Retroviral Agents; Child; Clinical; Computer Retrieval of Information on Scientific Projects Database; Development; Enrollment; Evaluation; Exposure to; Funding; Grant; Growth; Immunologics; Immunotherapy; Infant; Infection; Institution; Laboratories; Late Effects; Longitudinal Studies; Malignant Neoplasms; Metabolic Diseases; Neurologic; Neuropsychology; Opportunistic Infections; Outcome; Perinatal; Protocols documentation; Puberty; Purpose; Quality of life; Research; Research Personnel; Resources; Site; Source; Time; Toxic effect; United States National Institutes of Health; Vaccine Therapy; Woman; antiretroviral therapy; body system; follow-up; in utero; infancy; neuropsychological

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To describe late outcomes over time in relation to survival, growth, neurologic, and neuropsychological function, quality of life, organ system toxicity, metabolic disorders, development of oppotunistic infections and malignancies, and immunologic, and virologic parameters in HIV-infected infants, children, and adolescents. This will also include evaluation of potential late effects, impact of puberty, and complications of antiretroviral and immune therapy received by the subject. This study will also attempt to determine if uninfected infants born to HIV-infected women demonstrate any short or long-term adverse clinical or laboratory effects due to exposure to antiretroviral therapy or immune therapy/vaccines in utero, the perinatal period, or early infancy. This is a perspective, longitudinal study for long term follow-up of perinatally HIV-exposed infants, children, and adolescents, and children with post-perinatally acquired infection followed at PACTG site regardless of whether they are enrolled in PACTG protocols. The purpose of this study is to describe late outcomes over time in relation to survival, growth, neurologic and neuropsychologic function, quality of life, organ system toxicity, metabolic disorders, development of opportunistic infections and malignancies, and immunilogical, and virologic parameters in HIV-infected infants, children and adolescents. This will also include evaluation of potential late outcomes, impact of puberty, and complications of antiretroviral and immune therapy received by the subject. Moreover, to determine if uninfected infants born to HIV-infected women demonstrate any short or long term adverse clinical or laboratory effects due to exposure to antiretroviral therapy or immune therapy/vaccines in utero, the perinatal period, or early infancy.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 与生存，生长，神经系统和神经心理学功能有关，生活质量，器官系统毒性，代谢性疾病，对亲人感染和恶性肿瘤的发展以及免疫学和病毒学参数在HIV感染者，儿童，儿童和少女中的发展。这还将包括评估潜在的晚期作用，青春期影响以及受试者接受的抗逆转录病毒和免疫治疗的并发症。这项研究还将试图确定由于暴露于子宫内部，围产期或婴儿早期的抗逆转录病毒疗法或免疫治疗/疫苗而导致的艾滋病毒感染妇女出生的未感染的婴儿是否表现出任何短期或长期的不良临床或实验室影响。 这是一项观点，纵向研究，可长期随访暴露于周围HIV的婴儿，儿童和青少年，以及在pactg部位进行了腹部后获得感染的儿童，无论他们是否参加了PACTG方案。 这项研究的目的是描述与生存，生长，神经系统和神经心理学功能，生活质量，器官系统毒性，代谢性疾病，机会性感染和恶性肿瘤的发展以及免疫原状和病毒学参数的生存质量，生命质量，生活质量，机器人系统毒性，机器人系统毒性，机器人系统毒性，生长质量，生活质量，生活质量，生长质量，生活质量，生长质量，生活质量，生活质量，生长，生活质量，生活质量，生活质量，生长，生活质量，生活质量，生活质量，以及HEIV感染的婴儿，儿童和青少年的病毒学参数。 这还将包括评估潜在的晚期结局，青春期影响以及受试者接受的抗逆转录病毒和免疫治疗的并发症。 此外，要确定因艾滋病毒感染的妇女出生的未感染的婴儿是否表现出任何短期或长期不良临床或实验室影响，因为在子宫内，围产期或早期婴儿的子宫内接受抗逆转录病毒疗法或免疫治疗/疫苗。