NONINVASIVE VASCULAR DIAGNOSTIC DEVICE TO DISTINGUISH PREECLAMP FROM OTHR HYPERT

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Purpose: The hypertensive disorders of pregnancy (HDP) include preeclampsia (PE), gestational hypertension (GH), underlying chronic hypertension (CHTN), or PE superimposed on CHTN. Most maternal and fetal morbidity may be ascribed to PE and to the consequences of severe uncontrolled hypertension. PE is often difficult to distinguish from other HDP, as proteinuria may lag behind onset of hypertension (Wolf, 2004). This pilot study investigates utility of non-invasive indices of aortic stiffness (pulse wave velocity, PWV and augmentation index, AIx) for early diagnosis of PE. Study Design: Normotensive at term, CHTN at term, and clinically apparent primigravid women with PE (new onset hypertension and proteinuria) are recruited from our labor and delivery suite. Methods: Pulse wave analysis (PWA) by noninvasive applanation tonometry (SphygmoCorTM) is performed at radial and carotid arteries in supine and sitting positions. Heart Rate Variability (HRV) is determined via ECG using the same device in the supine position.