NONINVASIVE VASCULAR DEVICES- PREECLAMPSIA FROM OTHER HYPERTENSIVE DISORDERS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 目的：妊娠期高血压疾病(HDP)包括先兆子痫(PE)、妊娠期高血压(GH)、基础慢性高血压(CHTN)，或PE叠加CHTN。大多数母婴发病率可归因于PE和严重失控高血压的后果。PE通常很难与其他HDP区分开来，因为蛋白尿可能滞后于高血压的发病(Wolf，2004)。这项初步研究探讨了无创性的主动脉僵硬指标(脉搏波速度，PWV和增强指数，AIX)在PE早期诊断中的应用。研究设计：足月血压正常、足月CHTN和临床明显的初孕合并PE(新发高血压和蛋白尿)的妇女来自我们的分娩和分娩套件。方法：采用无创压平眼压计(SPhygmoCorTM)对仰卧位和坐位的颈动脉和桡动脉进行脉搏波分析(PWA)。心率变异性(HRV)是通过在仰卧位使用相同的设备通过心电图来确定的。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Purpose: The hypertensive disorders of pregnancy (HDP) include preeclampsia (PE), gestational hypertension (GH), underlying chronic hypertension (CHTN), or PE superimposed on CHTN. Most maternal and fetal morbidity may be ascribed to PE and to the consequences of severe uncontrolled hypertension. PE is often difficult to distinguish from other HDP, as proteinuria may lag behind onset of hypertension (Wolf, 2004). This pilot study investigates utility of non-invasive indices of aortic stiffness (pulse wave velocity, PWV and augmentation index, AIx) for early diagnosis of PE. Study Design: Normotensive at term, CHTN at term, and clinically apparent primigravid women with PE (new onset hypertension and proteinuria) are recruited from our labor and delivery suite. Methods: Pulse wave analysis (PWA) by noninvasive applanation tonometry (SphygmoCorTM) is performed at radial and carotid arteries in supine and sitting positions. Heart Rate Variability (HRV) is determined via ECG using the same device in the supine position.