CORE 2 DB4: PROTEASE PATHWAYS IN CAVEOLAE

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。驱动生物学项目4：定位于内皮细胞小窝中的蛋白水解酶经常合成为不活跃的酶原，然后被另一种蛋白水解酶激活，作为级联反应的一部分。这些蛋白质分解的级联过程通常是通过区隔作用来促进的。在过去的十年里，质膜微域在调节细胞信号方面的作用变得越来越明显。我们将检验小窝还有另一个作用的假设，即相互作用的蛋白酶的区隔。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Driving Biological Project 4: Protease Pathways Localized in Endothelial Cell Caveolae Proteases are frequently synthesized as inactive zymogens, and are then activated by another proteases, as part of a cascade. These cascades of proteolysis are frequently facilitated by compartmentalization. Over the last decade the role of plasma membrane microdomains, called caveolae, in regulating cell signaling has become increasingly apparent. We will test the hypothesis that caveolae have another role, the compartmentalization of interacting proteases