CORE 2 DB4: PROTEASE PATHWAYS IN CAVEOLAE

核心 2 DB4：小凹中的蛋白酶途径

• 批准号: 7380830
• 负责人: BONNIE F SLOANE
• 金额: $ 12.03万
• 依托单位: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7380830
• 关键词: CORE; DB4; PROTEASE; PATHWAYS; CAVEOLAE

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Driving Biological Project 4: Protease Pathways Localized in Endothelial Cell Caveolae Proteases are frequently synthesized as inactive zymogens, and are then activated by another proteases, as part of a cascade. These cascades of proteolysis are frequently facilitated by compartmentalization. Over the last decade the role of plasma membrane microdomains, called caveolae, in regulating cell signaling has become increasingly apparent. We will test the hypothesis that caveolae have another role, the compartmentalization of interacting proteases

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。驱动生物项目4：定位于内皮细胞小窝的蛋白酶途径蛋白酶通常作为无活性的酶原合成，然后被另一种蛋白酶激活，作为级联反应的一部分。这些级联的蛋白质水解往往促进区室化。在过去的十年中，质膜微区（称为小窝）在调节细胞信号传导中的作用变得越来越明显。我们将测试的假设，小窝有另一个作用，相互作用的蛋白酶区室化