CORE 2 DB4: PROTEASE PATHWAYS IN CAVEOLAE

核心 2 DB4：小凹中的蛋白酶途径

• 批准号: 7622859
• 负责人: BONNIE F SLOANE
• 金额: $ 11.16万
• 依托单位: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7622859
• 关键词: Automobile Driving; Biological; Caveolae; Cell membrane; Computer Retrieval of Information on Scientific Projects Database; Endopeptidases; Endothelial Cells; Enzyme Precursors; Funding; Grant; Institution; Localized; Membrane Microdomains; Pathway interactions; Peptide Hydrolases; Proteolysis; Research; Research Personnel; Resources; Role; Signal Transduction; Source; Testing; United States National Institutes of Health

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Driving Biological Project 4: Protease Pathways Localized in Endothelial Cell Caveolae Proteases are frequently synthesized as inactive zymogens, and are then activated by another proteases, as part of a cascade. These cascades of proteolysis are frequently facilitated by compartmentalization. Over the last decade the role of plasma membrane microdomains, called caveolae, in regulating cell signaling has become increasingly apparent. We will test the hypothesis that caveolae have another role, the compartmentalization of interacting proteases

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 驾驶生物学项目4：蛋白酶途径位于内皮细胞口腔中 蛋白酶经常被合成为无活性酶原，然后被另一种激活 蛋白酶，作为级联的一部分。这些级联的蛋白水解经常通过 分隔。在过去的十年中，质膜微域的作用称为 Caveolae在调节细胞信号方面已变得越来越明显。我们将检验假设 该小窝具有另一个作用，即相互作用的蛋白酶的分隔