CORE 2 DB4: PROTEASE PATHWAYS IN CAVEOLAE

核心 2 DB4：小凹中的蛋白酶途径

• 批准号: 7622859
• 负责人: BONNIE F SLOANE
• 金额: $ 11.16万
• 依托单位: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7622859
• 关键词: Automobile Driving; Biological; Caveolae; Cell membrane; Computer Retrieval of Information on Scientific Projects Database; Endopeptidases; Endothelial Cells; Enzyme Precursors; Funding; Grant; Institution; Localized; Membrane Microdomains; Pathway interactions; Peptide Hydrolases; Proteolysis; Research; Research Personnel; Resources; Role; Signal Transduction; Source; Testing; United States National Institutes of Health

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Driving Biological Project 4: Protease Pathways Localized in Endothelial Cell Caveolae Proteases are frequently synthesized as inactive zymogens, and are then activated by another proteases, as part of a cascade. These cascades of proteolysis are frequently facilitated by compartmentalization. Over the last decade the role of plasma membrane microdomains, called caveolae, in regulating cell signaling has become increasingly apparent. We will test the hypothesis that caveolae have another role, the compartmentalization of interacting proteases

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 驱动生物学项目4：位于内皮细胞小窝的蛋白酶通路 蛋白酶通常是作为无活性的酶原合成的，然后被另一种酶激活。 蛋白酶，作为级联的一部分。这些级联的蛋白质水解通常是促进 划分在过去的十年中，质膜微区的作用，称为 小窝在调节细胞信号传导中的作用越来越明显。我们将检验这个假设 小窝还有另一个作用，