CORE 2 DB4: PROTEASE PATHWAYS IN CAVEOLAE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 驱动生物学项目4：定位于内皮细胞小窝的蛋白酶通路 蛋白水解酶通常以不活跃的酵素形式合成，然后被另一种酶激活。 蛋白酶，作为级联反应的一部分。这些蛋白质分解的级联通常是由以下因素促进的 分隔化。在过去的十年中，质膜微域的作用被称为 小窝在调节细胞信号方面已经变得越来越明显。我们将检验这一假设 小窝还有另一个作用，即相互作用的蛋白酶的区隔。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Driving Biological Project 4: Protease Pathways Localized in Endothelial Cell Caveolae Proteases are frequently synthesized as inactive zymogens, and are then activated by another proteases, as part of a cascade. These cascades of proteolysis are frequently facilitated by compartmentalization. Over the last decade the role of plasma membrane microdomains, called caveolae, in regulating cell signaling has become increasingly apparent. We will test the hypothesis that caveolae have another role, the compartmentalization of interacting proteases