A strategy for rapid directed modification of protein binding properties

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Development of new protein-based drugs would be greatly helped if there was a straightforward and rapid method by which proteins could be changed so they would bind more specifically and strongly to their targets within the body. This would allow drugs with fewer side effects and higher potency to be made. In addition, changing proteins so they can bind to new disease targets would allow new types of drugs to be developed. This project aims to establish and test a novel method for changing protein binding very much more easily and rapidly than ever before.