HPA AXIS ALTERATIONS IN PTSD: A COMPARISON OF GULF WAR AND VIETNAM VETERANS

PTSD 中 HPA 轴的变化：海湾战争和越南退伍军人的比较

• 批准号: 7380543
• 负责人: JULIA GOLIER
• 金额: $ 7.56万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-17 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7380543
• 关键词: southeast Asia; veterans; war /peace

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We intend to study Gulf War veterans with PTSD, Vietnam veterans with PTSD, and age-comparable healthy veterans without PTSD using an expanded neuroendocrine battery. We propose to test four different models of HPA axis dysfunction that may explain low cortisol levels in PTSD: adrenal impairment, reduced pituitary sensitivity, reduced hypothalamic CRF release, or enhanced negative feedback inhibition. To discriminate among these possibilities we will measure basal activity of the HPA axis and the response to three challenge tests: the CRF stimulation test, low-dose ACTH test, and the low dose dexamethasone suppression (DST) test. Hypothesis: we will test the hypothesis that the neuroendocrine profile of Gulf War veterans with PTSD will suggest evidence of adrenal impairment as compared to healthy veterans and that the profile of Vietnam veterans with PTSD will be consistent with enhanced negative feedback inhi

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。我们打算研究海湾战争退伍军人与创伤后应激障碍，越南退伍军人与创伤后应激障碍，和年龄相当的健康退伍军人没有创伤后应激障碍使用扩展神经内分泌电池。我们建议测试四种不同的模型HPA轴功能障碍，可以解释低皮质醇水平的PTSD：肾上腺损伤，垂体敏感性降低，减少下丘脑CRF释放，或增强负反馈抑制。为了区分这些可能性，我们将测量HPA轴的基础活性和对三种激发试验的反应：CRF刺激试验、低剂量ACTH试验和低剂量地塞米松抑制（DST）试验。假设：我们将检验以下假设：与健康退伍军人相比，海湾战争退伍军人创伤后应激障碍的神经内分泌特征将提示肾上腺损伤的证据，而越南退伍军人创伤后应激障碍的特征将与增强的负反馈一致。