PET STUDY ON THE EFFECTS OF PCT FOR PANIC DISORDER ON BRAIN FUNCTION

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。许多神经成像研究现在表明，焦虑症患者，包括那些患有恐慌症的患者，在急性焦虑和恐惧期间，PFC活动减少。尤其是PFC的一个亚区，即眼眶额叶皮质(OFC)，似乎更容易出现这种现象。在目前拟议的试点研究中，我们将首先使用PET扫描来证明，与正常对照组相比，惊恐障碍患者在呼吸刺激剂多沙普兰诱导惊恐发作之前和期间，OFC的活动减少，杏仁核的活动增加。然后，我们将试图证明，成功地使用惊恐控制疗法(PCT)治疗惊恐障碍将使重复PET扫描和多沙普兰治疗期间的这些反应正常化。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A number of neuroimaging studies have now shown that patients with anxiety disorder, including those with panic disorder, show a reduction in PFC activity during acute anxiety and fear. In particular, a subregion of PFC, the orbital frontal cortex (OFC), seems prone to this phenomenon. In the present proposed pilot study we will use PET scans first to demonstrate that compared to normal controls, patients with panic disorder show decreased activity in the OFC and increased activity in the amygdala before and during the induction of a panic attack with the respiratory stimulant doxapram. Then, we will attempt to show that successful treatment of panic disorder with Panic Control Therapy (PCT) will normalize these responses during repeat PET scan and doxapram administration.