Neural Circuitry of Social Behavior in Bonnet Macaques

帽猕猴社会行为的神经回路

• 批准号: 6733243
• 负责人: JACK M. GORMAN
• 金额: $ 16.26万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-16 至 2004-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6733243
• 关键词: Macaca; amygdala; aspartate; behavior test; behavioral /social science research tag; bioimaging /biomedical imaging; brain; brain imaging /visualization /scanning; brain morphology; choline; corpus striatum; educational resource design /development; ethology; immature animal; interdisciplinary collaboration; magnetic resonance imaging; neuroanatomy; neurophysiology; nuclear magnetic resonance spectroscopy; prefrontal lobe /cortex; psychobiology; psychological stressor; social behavior; videotape /videodisc

DESCRIPTION (provided by applicant): In attempting to understand the fundamental neurobiology of social behavior, a primate animal model would be ideal. The bonnet macaque (Macaca radiata) is a particularly good example of a species of nonhuman primate that exhibits a range of sophisticated social behaviors. In this proposal, we propose a collaboration between a biobehavioral primatology laboratory and a clinical neuroimaging group to explore, develop, and implement methods that would allow for the study of specific neurobiological substrates modulating aspects of primate social behavior. First, we plan to conduct baseline magnetic resonance imaging studies, including volumetric analyses, magnetic resonance spectroscopy, and diffusion tensor imaging, in 24 bonnets early in development in order to characterize a profile of brain structure and function which is reflected in social performance. The major region of interest is the corpus striatum, reflecting a convergence of evidence of this region's role in modulating brain reward pathways, which might subserve a primate's reinforcement to engage in social activity. Second, to assess social behavior, we will develop a series of video simulations of social interactions that can be used to test bonnets' differentiable responsivity, enabling the study of social behavior under controlled and quantifiable conditions. The study's main hypotheses are that there will be a continuum of striatal pathology among the 24 bonnets as measured by the 3 imaging modalities, and those bonnets who display the most pathological imaging profiles will display less social engagement when confronted with live social interactions than when confronted with social video encounters. If confirmed, this suggests that abnormal striatal "viability" impedes a primate's overall social dexterity and drive for social interaction. A secondary aim of this project is to develop an educational and future research component, which will include a research apprenticeship and opportunities for graduate and undergraduate students to work in social neuroscience-related projects. Ultimately, this knowledge will contribute to a better understanding of the biobehavioral processes related to social behavior, with relevance to disorders such as schizophrenia, social anxiety disorder, autism, and personality disorders involving disruption of interpersonal social behavior.

描述（由申请人提供）：在试图了解社会行为的基本神经生物学时，灵长类动物模型是理想的。帽猕猴（Macaca radiata）是非人类灵长类动物的一个特别好的例子，它表现出一系列复杂的社会行为。在本提案中，我们提议生物行为灵长类动物学实验室和临床神经影像学小组之间进行合作，探索、开发和实施方法，以研究调节灵长类动物社会行为方面的特定神经生物学底物。首先，我们计划在开发初期对 24 顶帽子进行基线磁共振成像研究，包括体积分析、磁共振波谱和扩散张量成像，以表征社会表现中反映的大脑结构和功能概况。主要感兴趣的区域是纹状体，反映了该区域在调节大脑奖励途径中的作用的证据的汇聚，这可能有助于灵长类动物参与社会活动的强化。其次，为了评估社会行为，我们将开发一系列社会互动的视频模拟，可用于测试引擎盖的可微响应性，从而能够在受控和可量化的条件下研究社会行为。该研究的主要假设是，通过 3 种成像方式测量的 24 个帽子之间将存在纹状体病理学的连续体，并且那些表现出最病理性成像特征的帽子在面对实时社交互动时表现出的社交参与度将低于面对社交视频遭遇时的社交参与度。如果得到证实，这表明异常的纹状体“活力”会阻碍灵长类动物的整体社会灵活性和社会互动的动力。该项目的第二个目标是开发教育和未来研究部分，其中包括研究学徒以及研究生和本科生从事社会神经科学相关项目的机会。最终，这些知识将有助于更好地理解与社会行为相关的生物行为过程，以及与精神分裂症、社交焦虑症、自闭症和涉及人际社会行为破坏的人格障碍等疾病相关的疾病。