MRI STUDIES IN DEPRESSION

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。尽管众所周知，压力、焦虑和抑郁是相互关联的，但焦虑和应激性生活事件对抑郁症神经生物学观察的影响还没有得到明确的检验。压力和焦虑可能会引发一系列神经生物学事件，包括激活身体的主要应激防御系统，以及激活与获得和维持恐惧有关的大脑回路。在这项研究中，磁共振成像(MRI)技术，包括形态测量MRI，磁共振波谱(MRS)，和功能MRI将被用来检查压力和焦虑在调节抑郁症的结构、化学和功能措施方面的滚动。基于抑郁症的神经解剖学模型，我们将重点关注两个已知易受压力影响的大脑主要区域：海马体和前额叶皮质。抑郁的受试者将根据共病焦虑和早期和近期创伤/压力的病史进行彻底的表征。四名抑郁症受试者和四名匹配的健康对照组，在Mt.西奈医学中心将接受形态核磁共振、MRS和功能磁共振测试。所有抑郁症患者将在用SSRI氟西汀治疗后进行重新测试，反应状态和临床措施的变化作为协变量包括在数据分析中。这四个健康对照将被重新测试，作为可靠性的衡量标准。该方案的主要优势在于对跨模式数据的分析，允许以综合的方式探索有关神经化学和功能之间的关系以及焦虑对抑郁症神经生物学结果的影响的问题。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Despite the well-known assocation of stress, anxiety and depression, the impact of anxiety and stressful life events on the neurobiological observations reported in depression have not been clearly examined. Stress and anxiety may set in motion a series of neurobiological events including activation of the body's major stress-defense systems and activation of brain circuitry involved in the acquisition and maintenance of fear. In this study, magnetic resonance imaging (MRI) techniques, including morphometric MRI, magnetic resonance spectroscopy (MRS), and functional MRI will be used to examine the roll of stress and anxiety in modulating structural, chemical and functional measures of depression. Based on neuroanatomical models of depression, we will focus on two main brain areas, both known to be vulnerable to stress: the hippocampus and the prefrontal cortex. Depressed subjects will be thoroughly characterized on measures of comorbid anxiety and history of early and recent trauma/stress. Four depressed subjects and four matched healthy controls, recruited at Mt. Sinai Medical Center, will undergo morphometric MRI, MRS, and functional MRI testing. All depressed patients will be re-tested post-treatment with the SSRI fluoxetine, with response status and change in clinical measures included as covariates in the data analyses. The four healthy controls will be re-tested as a measure of reliability. A major strength of this protocol lies in the analysis of cross-modal data, allowing the exploration of questions about the relationship between neurochemistry and function, and the influence of anxiety on neurobiological findings in depression, in an integrative manner.