GENETICS OF SALT SENSITIVE HYPERTENSION

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。盐敏感型高血压遗传学研究旨在研究盐敏感型高血压非裔美国同胞的遗传学，并进一步确定盐敏性高血压的细胞和分子机制。500名患有1期和/或2期高血压的非洲裔美国同胞将接受低钠饮食，低于20MEQ，为期1周。参与者将有完整的病史、身体和实验室评估，包括基因分型。如果有必要，这些参与者也将被要求停止目前的降压药物，并将开始另一种(阿达拉)为期3周的药物。在此之后，患者被指示停止所有抗高血压药物，为研究的饮食阶段做准备，该研究也将持续一周。在整个研究过程中，患者都要频繁地检查血压。在出院之前，如果有必要，对患者进行医学评估，并恢复研究前的抗高血压药物治疗。初级保健医生会被告知病人的参与。研究中还招募了大约350名对照参与者和兄弟姐妹的父母。他们的参与仅限于简短的病史、血压评估和/或抽血进行基因分型。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Genetics of Salt Sensitive Hypertension Study is designed to examine genetics in salt-sensitive hypertensive African-American siblings as well as to further define cellular and molecular mechanisms of salt-sensitive hypertension. 500 African-American sibships with stage 1 and/or 2 hypertension will receive a low sodium diet, less than 20 meq, for 1 week. The participants will have a complete history, physical and laboratory evaluation including genotyping. If necessary, such participants will also be asked to stop current anti-hypertensive medication and will be started on another (Adalat) for 3 weeks. After such, the patients are instructed to stop all anti-hypertensive medication to prepare for the diet phase of the study which will also last for 1 week. Throughout the study the patients have frequent blood pressure checks. Prior to release from the study, patients are medically evaluated and pre-study anti-hypertensive medication resumed, if necessary. Primary care physicians are notified of patient participation. About 350 control participants and parents of siblings in the study are recruited as well. Their participation is limited to a brief medical history, blood pressure evaluation and/or a blood draw for genotyping.