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The Role of ALIX during Multivesicular Body Biogenesis

ALIX 在多泡体生物发生过程中的作用

基本信息

批准号：
BB/E019919/1
负责人：
Philip Woodman
金额：
$ 57.12万
依托单位：
University of Manchester
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2008
资助国家：
英国
起止时间：
2008 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=BB%2FE019919%2F1
关键词：
Role ALIX during Multivesicular Body

项目摘要

The rate at which cells grow and divide is controlled by signals from their environment. Amongst the most important of these is in the form of circulating small proteins called growth factors. These bind to receptors located on the cell's outer surface (or membrane), causing them to alter their pattern of interactions with molecules inside the cell that control cell growth. Growth factor receptors therefore act as essential bridges between the cell exterior and interior. In order to prevent responses continuing in an uncontrolled fashion, receptors must be removed from the cell surface shortly after growth factor binding and sent to a specialised cellular compartment called the lysosome, where they are degraded. Receptors first move from the cell surface to an internal, membrane-enclosed compartment called the endosome. Here the receptor is concentrated into regions of membrane that bud inwardly into the content space of the endosome, and are then directed to the lysosome. Precisely how inward budding occurs is not known. This proposal aims to dissect the molecular mechanisms underlying this process by using a range of cell biological and biochemical techniques.

细胞生长和分裂的速度由来自环境的信号控制。其中最重要的是循环小蛋白质（称为生长因子）的形式。它们与位于细胞外表面（或膜）上的受体结合，导致它们改变与细胞内控制细胞生长的分子的相互作用模式。因此，生长因子受体充当细胞外部和内部之间的重要桥梁。为了防止反应以不受控制的方式持续，受体必须在生长因子结合后不久从细胞表面去除，并发送到称为溶酶体的特殊细胞区室，在那里它们被降解。受体首先从细胞表面移动到内部的膜封闭室，称为内体。在这里，受体集中到膜区域，这些区域向内芽进入内涵体的内容空间，然后被引导至溶酶体。内芽到底是如何发生的尚不清楚。该提案旨在通过使用一系列细胞生物学和生化技术来剖析这一过程背后的分子机制。

项目成果

期刊论文数量（4）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

ESCRT proteins, endosome organization and mitogenic receptor down-regulation.

ESCRT 蛋白、内体组织和促有丝分裂受体下调。

DOI：
10.1042/bst0370146
发表时间：
2009
期刊：
Biochemical Society transactions
影响因子：
3.9
作者：
Woodman P
通讯作者：
Woodman P

Structural Basis for Selective Interaction between the ESCRT Regulator HD-PTP and UBAP1.

DOI：
10.1016/j.str.2016.10.006
发表时间：
2016-12-06
期刊：
STRUCTURE
影响因子：
5.7
作者：
Gahloth, Deepankar;Levy, Colin;Heaven, Graham;Stefani, Flavia;Wunderley, Lydia;Mould, Paul;Cliff, Matthew J.;Bella, Jordi;Fielding, Alistair J.;Woodman, Philip;Tabernero, Lydia
通讯作者：
Tabernero, Lydia

Multivesicular bodies: co-ordinated progression to maturity.