RENAL DISEASE PROGRESSION GENES AND ENVIRONMENTAL IMPACT ON DIABETIC NEPHROPATHY

肾病进展基因和环境对糖尿病肾病的影响

• 批准号: 7377988
• 负责人: JEFFREY R SCHELLING
• 金额: $ 3.35万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7377988
• 关键词: RENAL; DISEASE; PROGRESSION; GENES; ENVIRONMENTAL

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Diabetic nephropathy (DN) is the leading cause of chronic renal disease in the world. Though some modifiable risk factors have been identified, data from Caucasians and Pima Indians indicate that DN is genetically determined. The investigators hypothesize that the intermediate phenotypes, proteinuria and glomerular filtration rate (GFR) change, which respectively predict and measure progression of diabetic nephropathy to End-Stage Renal Disease (ESRD), are heritable. The hypothesis will be tested in a longitudinal study of African American (AA) and Caucasian families, which will permit the natural history of DN in AA to be defined for the first time. Data will be generated by quantitative trait locus (QLA) analysis, which offers advantages to the ongoing strategies, including enrollment and better definition of the clinical course of DN subjects with intermediate phenotypes (e.g. microalbuminuria), which have previously been excluded in genetic analyses. Their diabetic siblings will be phenotyped and followed longitudinally. Dependent outcomes will include yearly urine albumin excretion and GFR measurements. Target accrual is 900 subjects with 450 at MetroHealth Medical Center.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中得到体现。列出的机构是中心的机构，不一定是研究者的机构。糖尿病肾病（DN）是世界上慢性肾脏疾病的主要原因。尽管已经确定了一些可改变的风险因素，但来自白种人和皮马印第安人的数据表明 DN 是由基因决定的。研究人员假设，中间表型、蛋白尿和肾小球滤过率（GFR）变化（分别预测和测量糖尿病肾病进展为终末期肾病（ESRD））是可遗传的。该假设将在非裔美国人 (AA) 和白种人家庭的纵向研究中得到检验，这将首次定义 AA 中 DN 的自然史。数据将通过数量性状基因座 (QLA) 分析生成，这为正在进行的策略提供了优势，包括招募和更好地定义具有中间表型（例如微量白蛋白尿）的 DN 受试者的临床病程，这些受试者以前在遗传分析中被排除在外。 他们的糖尿病兄弟姐妹将被进行表型分析并进行纵向追踪。相关结果包括每年的尿白蛋白排泄量和 GFR 测量。目标应计人数为 900 名受试者，其中 450 名受试者在 MetroHealth 医疗中心。