CHRONIC RENAL INSUFFICIENCY COHORT (CRIC)

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定是研究者机构。慢性肾功能不全（CRI）被认为是一种无声的流行病，影响着1000多万美国人。与CRI相关的发病率和死亡率负担来自CRI向终末期肾病（ESRD）的频繁进展以及CRI背景下CVD的不成比例风险。 CRIC研究的主要目标是在不同严重程度的慢性肾功能不全（CRI）患者中检查CRI和心血管疾病（CVD）的风险因素，并开发预测模型以识别CRI的高风险亚组。这是一项为期六年的观察研究。审评委的研究将在以下四个领域收集大量数据：1）社会人口统计学、合并症、治疗、人体测量、社会心理、生活质量和卫生保健资源利用测量，包括血压测量、药物暴露数据、饮食摄入评估、体力活动和生活质量，2）肾功能测量，包括肾小球滤过率（GFR），微量白蛋白尿和蛋白尿作为CVD肾病进展的风险因素，3）心血管测量和4）生化测量。 CRIC研究将在CRI严重程度范围内招募3000名成人，以确保足够数量的患者达到主要研究终点。250人将参加MHMC。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Chronic Renal Insufficiency (CRI) is recognized as a silent epidemic affecting more than 10 million Americans. The burden of morbidity and mortality associated with CRI derives from the frequent progression of CRI toward End Stage Renal Disease (ESRD) and the disproportionate risk of CVD in the setting of CRI. The principal goals of the CRIC Study are to examine risk factors for chronic renal insufficiency (CRI) and cardiovascular disease (CVD) among patients with varying severity of CRI, and to develop predictive models to identify high-risk subgroups with CRI. This is a six year observation study. Extensive data will be collected for the CRIC study in the following four areas: 1) sociodemographic, comorbidity, treatment, anthropometric, psychosocial, quality of life and health care resource utilization measures including blood pressure measures, drug exposure data, assessment of dietary intake, physical activity, and quality of life, 2) renal function measures including glomerular filtration rate (GFR), microalbuminuria and proteinuria as risk factors for renal disease progression for CVD, 3) cardiovascular measures and 4) biochemical measures. The CRIC Study will enroll 3000 adults across the spectrum of severity of CRI to assure that a sufficient number of patients reach the primary study endpoint. 250 will participate at MHMC.