CHRONIC RENAL INSUFFICIENCY COHORT (CRIC)

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Chronic Renal Insufficiency (CRI) is recognized as a silent epidemic affecting more than 10 million Americans. The burden of morbidity and mortality associated with CRI derives from the frequent progression of CRI toward End Stage Renal Disease (ESRD) and the disproportionate risk of CVD in the setting of CRI. The principal goals of the CRIC Study are to examine risk factors for chronic renal insufficiency (CRI) and cardiovascular disease (CVD) among patients with varying severity of CRI, and to develop predictive models to identify high-risk subgroups with CRI. This is a six year observation study. Extensive data will be collected for the CRIC study in the following four areas: 1) sociodemographic, comorbidity, treatment, anthropometric, psychosocial, quality of life and health care resource utilization measures including blood pressure measures, drug exposure data, assessment of dietary intake, physical activity, and quality of life, 2) renal function measures including glomerular filtration rate (GFR), microalbuminuria and proteinuria as risk factors for renal disease progression for CVD, 3) cardiovascular measures and 4) biochemical measures. The CRIC Study will enroll 3000 adults across the spectrum of severity of CRI to assure that a sufficient number of patients reach the primary study endpoint. 250 will participate at MHMC.