Continuation of the Chronic Renal Insufficiency Cohort (CRIC) Study

慢性肾功能不全队列 (CRIC) 研究的继续

• 批准号: 8113064
• 负责人: HAROLD I FELDMAN
• 金额: $ 30.26万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2012-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8113064
• 关键词: Address; Adult; Adverse event; Advisory Committees; Affect; American; Ancillary Study; Area; Arts; Award; Biochemical; Biochemistry; Biological Markers; Biometry; Cardiology; Cardiovascular Diseases; Cardiovascular system; Categories; Cessation of life; Characteristics; Chronic Kidney Failure; Chronic Kidney Insufficiency; Clinical; Clinical Research; Cohort Studies; Communication; Complement; Confidentiality; Data; Data Analyses; Data Collection; Data Coordinating Center; Data Quality; Development; Device or Instrument Development; Diagnostic Imaging; Disease; Echocardiography; Electrocardiogram; Electron Beam; End stage renal failure; Enrollment; Ensure; Epidemic; Epidemiology; Evaluation; Event; Film; Functional disorder; Funding; Genotype; Goals; Health; Health Status; Internet; Intervention; Investigation; Kidney; Kidney Diseases; Kidney Failure; Knowledge; Laboratories; Lead; Leadership; Logistics; Manuscripts; Measures; Medical center; Modeling; Monitor; Morbidity - disease rate; National Institute of Diabetes and Digestive and Kidney Diseases; Nephrology; Online Systems; Outcome; Participant; Patients; Pennsylvania; Phase; Physiological; Preventive; Procedures; Process; Protocols documentation; Randomized Controlled Trials; Reading; Reporting; Research; Research Activity; Research Personnel; Resources; Risk; Risk Factors; Science; Scientist; Security; Site; Specimen; Subgroup; System; Techniques; Testing; Ultrasonography; United States National Institutes of Health; Universities; X-Ray Computed Tomography; abstracting; base; cardiovascular risk factor; clinical epidemiology; cohort; data management; design; disease natural history; distributed data; experience; follow-up; high risk; improved; meetings; member; programs; prospective; quality assurance; repository; sample collection; success; treatment trial

DESCRIPTION (provided by applicant): This is an application from the Center for Clinical Epidemiology and Biostatistics (CCEB) at the University of Pennsylvania Medical Center to continue serving as the Scientific and Data Coordinating Center (SDCC) for the Chronic Renal Insufficiency Cohort (CRIC) Study. Chronic renal insufficiency (CRI) affects over 10 million Americans. Their burden of morbidity derives from their frequent progression to end-stage renal disease (ESRD) and disproportionate risk of cardiovascular events. A shared set of etiological factors is being identified as potentially responsible for both progressive renal disease and cardiovascular disease (CVD) including clinical and biomarkers. Characterizing relationships between these risk factors and outcomes will permit development of instruments to predict poor outcomes in patients with CRI and enhance understanding of etiological mechanisms leading to these outcomes. Between 2001-2007, the Prospective Chronic Renal Insufficiency Cohort (CRIC) Study enrolled >3600 adults with chronic kidney disease to address overarching goals of identifying predictors of rapid progression of kidney disease and clarifying the relationship between kidney dysfunction and the risks of subclinical and clinical cardiovascular events, death, and resource utilization through an initial 5-year follow-up. Under the leadership of investigators at Penn, subject recruitment and retention have exceeded goals and the quality of data has been outstanding. In addition, the CRIC Ancillary Studies Program has been remarkably successful in expanding the scientific scope of CRIC through 23 funded federal awards. The proposed Phase 2 of CRIC, which extends follow-up through 2013, offers a unique opportunity to leverage the existing effort and success of CRIC to establish a cohort of participants with chronic kidney disease who have long-term prospective follow-up on progression of kidney disease and a variety of outcomes including post-end-stage renal disease health status. This unparalleled resource will expand the science related to chronic kidney disease natural history as well as the impact on cardiovascular disease and other adverse events. The overarching specific aims of the CRICSDCC in Phase II include: 1) set and promote a Chronic Kidney Disease Research Agenda, 2) lead the conduct of all aspects of CRIC Phase II, 3) develop processes to promote randomized, controlled trials in CKD, and 4) facilitate interactions with other clinical studies to promote collaborative CRI research.

描述（由申请人提供）：