INSULIN AND SARCOPENIA IN THE ELDERLY

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。肌肉质量和力量随着年龄的增长而逐渐下降。这一过程被称为骨质疏松症，并与跌倒和骨折的风险增加有关，这增加了在养老院住院的风险。此外，肌肉质量和力量的减少会导致体力活动的减少，这可能会造成骨骼虚弱、肥胖和糖尿病等后果。具体目的和步骤：1.比较健康老年人和年轻对照组肌肉(生长和缺失)对胰岛素的反应。这将使我们能够检验这一假设，即健康老年人的肌肉蛋白质合成对胰岛素的反应受到损害。2.比较健康青年受试者与青年2型糖尿病受试者、老年健康受试者与老年2型糖尿病受试者的血糖和肌肉蛋白质代谢(合成和分解)对胰岛素的反应。通过这种方式，我们将检验这一假设，即肌肉对胰岛素的反应缺陷只与年龄有关，与糖尿病无关。志愿者将通过IRB批准的广告招募，该广告将在UTMB、当地报纸和社交中心张贴，并通过口碑传播。志愿者将被告知研究的风险和好处，并将被要求签署一份批准的同意书。我们希望了解随着年龄的增长肌肉的丧失是否是由于老年人胰岛素生长肌肉的能力发生了变化，以及这是否与糖尿病有关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Muscle mass and strength progressively decline with aging. This process has been termed sarcopenia, and is associated with increased risk of falls and bone fracture, which increase the risk of admission in nursing homes. Further, decreases in muscle mass and strength can lead to a reduction in physical activity, which may have possible effects including weak bone, obesity, and diabetes. Specific Aims and Procedures: 1. To compare the response of muscle (growth and loss) to insulin between healthy seniors and younger controls. This will allow us to test the hypothesis that the response of muscle protein synthesis to insulin is impaired in the healthy seniors. 2. To compare the response of glucose and muscle protein turnover (synthesis and breakdown) to insulin between healthy younger volunteers and younger type 2 diabetic volunteers, and between healthy senior volunteers and senior type 2 diabetic volunteers. In this way we will test the hypothesis that the defect in the response of muscles to insulin is only age-dependent and unrelated to diabetes. Volunteers will be recruited by an IRB-approved advertisement that will be posted at UTMB, local newspapers, and social centers, and by word of mouth. The volunteers will be informed about the risks and the benefits of the studies and will be asked to sign an approved consent form. We hope to learn if the loss of muscle with aging is due to changes in the ability of insulin to grow muscle in senior citizens, and if this is related or not to diabetes.