CLINICAL TRIAL: NUTRITIONAL INTERVENTIONS FOR MAXIMAL MUSCLE GAIN IN MIDDLE-AGED

临床试验：中年人最大肌肉增长的营养干预

• 批准号: 7952163
• 负责人: Elena Volpi
• 金额: $ 1.58万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7952163
• 关键词: Aging; Amino Acids; Clinical Research; Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Data; Dietary Intervention; Dose; Enrollment; Essential Amino Acids; Exercise; Funding; Grant; Growth; Institution; Muscle; Muscle Weakness; Nutritional; Persons; Pilot Projects; Placebos; Prevention; Randomized; Research; Research Personnel; Resources; Safety; Source; Supplementation; Testing; Training; United States National Institutes of Health; dietary supplements; middle age; pill; safety testing; sedentary; sugar

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our studies in the past have focused on the short term effects of exercise and amino acids in sedentary subjects. We would like to expand our research to include recreationally active middle aged people looking at the effect of essential amino acid on muscle growth. We hypothesize that long-term nutritional supplementation with essential amino acids will grow muscle and increase strength in healthy, trained middle-aged people. We will determine if long-term nutritional supplementation with essential amino acids can grow muscle and increase strength in healthy, trained middle aged people. Enrolled subjects will be randomized to receive supplement or a placebo (i.e. like a sugar pill ) every day for one year. They will be tested every four months to check for muscle growth, strength testing, and safety of the supplements. At the end of the year all tests will be performed again to get the final results. This pilot study will serve to determine feasibility and safety of a nutritional intervention for muscle growth in trained middle-aged persons, and will allow us to collect preliminary data for a larger clinical trial to determine the optimal dose and composition of nutritional supplements for the prevention of muscle weakness and loss with aging.

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