CLINICAL TRIAL: INSULIN AND SARCOPENIA IN THE ELDERLY (CYCLE NO, 2)

临床试验：老年人的胰岛素和肌肉减少症（第 2 周期）

• 批准号: 7719189
• 负责人: Elena Volpi
• 金额: $ 5.76万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719189
• 关键词: Aging; Amino Acids; Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Defect; Dependence; Disodium Salt Nitroprusside; Elderly; Exercise; Fracture; Funding; Future; Goals; Grant; Injury; Institution; Insulin; Insulin Resistance; Intervention; Measures; Metabolism; Muscle; Muscle Proteins; Prevention; Process; Protein Biosynthesis; Randomized; Rate; Research; Research Personnel; Resources; Risk; Solid; Source; United States National Institutes of Health; age related; base; falls; muscle metabolism; omega-N-Methylarginine; prevent; response; sarcopenia

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Muscle mass and function progressively decline with aging. This process has been termed sarcopenia, and is associated with increased risk of falls and vulnerability to injury, especially bone fracture, which increase the risk of functional dependence. Our preliminary results suggest that there is a change in the response of muscle protein synthesis to insulin in the elderly, which can compromise the positive effect of amino acids on muscle protein gain. Our goal is to determine the mechanisms underlying the age-related insulin resistance of muscle proteins, which will allow us to define specific interventions to target this defect and provide the scientific basis for the prevention and treatment of sarcopenia. Subjects will be assigned randomly to any of the following groups: for 18-35 years old the possible groups are the following: insulin alone, insulin with L-NMMA, L-NMMA alone; meal ; for 65 or older the possible groups will be the following: insulin alone, insulin with sodium nitroprusside; insulin with exercise; meal alone; meal with sodium nitroprusside; meal with exercise. We will measure the rate of metabolism, exchange, or turnover of amino acids in the body. Overall, we believe that this proposal will allow us to better delineate the changes in muscle metabolism with aging, thus providing a solid scientific basis for future intervention to prevent and treat muscle loss with aging (sarcopenia).

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 随着年龄的增长，肌肉质量和功能逐渐下降。该过程被称为肌肉减少症，并且与增加的福尔斯风险和对损伤的脆弱性相关，尤其是骨折，这增加了功能依赖的风险。 我们的初步结果表明，老年人肌肉蛋白质合成对胰岛素的反应发生了变化，这可能会损害氨基酸对肌肉蛋白质获得的积极作用。 我们的目标是确定与年龄相关的肌肉蛋白胰岛素抵抗的机制，这将使我们能够确定针对这种缺陷的具体干预措施，并为预防和治疗肌肉减少症提供科学依据。 受试者将被随机分配至以下任何一组：对于18-35岁的受试者，可能的组如下：胰岛素单药治疗、胰岛素+L-NMMA、L-NMMA单药治疗;对于65岁或以上的受试者，可能的组如下：胰岛素单药治疗、胰岛素+硝普钠、胰岛素+运动、单独进餐、胰岛素+硝普钠、进餐+运动。我们将测量体内氨基酸的代谢率、交换率或周转率。 总的来说，我们相信这一建议将使我们能够更好地描绘肌肉代谢随衰老的变化，从而为未来干预预防和治疗肌肉衰老（肌肉减少症）提供坚实的科学基础。