FREE RADICALS, MEMBRANES AND ENZYME PHOTOACTIVATION

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。动脉斑块的形成是脂蛋白氧化的结果，尤其是低密度脂蛋白。目的：探讨低密度脂蛋白(LDL)中脂类和蛋白质自由基氧化的调控机制。低密度脂蛋白是从新鲜的人血中分离出来的，并暴露在自由基团的引发剂中。低密度脂蛋白氧化产物被分离出来，并评估了天然和人造抗氧化剂的效果。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Development of arterial plaque results from oxidation of lipoproteins, particularly low-density lipoproteins. SPECIFIC AIM: The objective of this study is to determine the mechanisms governing the free radical oxidation of lipids and proteins in low-density lipoproteins (LDL). LDL are isolated from fresh human blood and exposed to free redical initiators. Products of LDL oxidation are isolated and the effect of natural and man-made antioxidants are assessed.