FREE RADICALS, MEMBRANES AND ENZYME PHOTOACTIVATION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 动脉斑块的形成是脂蛋白氧化的结果，尤其是低密度脂蛋白。 特定目标： 本研究的目的是确定低密度脂蛋白(LDL)中脂类和蛋白质的自由基氧化机制。低密度脂蛋白是从新鲜的人血中分离出来的，并暴露在自由基团的引发剂中。低密度脂蛋白氧化产物被分离出来，并评估了天然和人造抗氧化剂的效果。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Development of arterial plaque results from oxidation of lipoproteins, particularly low-density lipoproteins. SPECIFIC AIM: The objective of this study is to determine the mechanisms governing the free radical oxidation of lipids and proteins in low-density lipoproteins (LDL). LDL are isolated from fresh human blood and exposed to free redical initiators. Products of LDL oxidation are isolated and the effect of natural and man-made antioxidants are assessed.