FREE RADICALS, MEMBRANES AND ENZYME PHOTOACTIVATION

自由基、膜和酶光活化

• 批准号: 7605523
• 负责人: Ned Allen Porter
• 金额: $ 0.05万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7605523
• 关键词: Antioxidants; Blood; Computer Retrieval of Information on Scientific Projects Database; Development; Enzymes; Free Radicals; Funding; Grant; Human; Institution; Lipids; Lipoproteins; Low Density Lipoprotein oxidation; Low-Density Lipoproteins; Membrane; Proteins; Research; Research Personnel; Resources; Source; United States National Institutes of Health; oxidation; photoactivation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Development of arterial plaque results from oxidation of lipoproteins, particularly low-density lipoproteins. SPECIFIC AIM: The objective of this study is to determine the mechanisms governing the free radical oxidation of lipids and proteins in low-density lipoproteins (LDL). LDL are isolated from fresh human blood and exposed to free redical initiators. Products of LDL oxidation are isolated and the effect of natural and man-made antioxidants are assessed.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 脂蛋白氧化，尤其是低密度脂蛋白的氧化引起的动脉斑块的发展。 具体目的： 这项研究的目的是确定低密度脂蛋白（LDL）中脂质和蛋白质自由基氧化的机制。 LDL与新鲜的人体血液中分离出来，并暴露于自由恢复启动器中。 LDL氧化产物分离出来，并评估天然和人造抗氧化剂的作用。