FREE RADICALS, MEMBRANES AND ENZYME PHOTOACTIVATION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 动脉斑块的形成是脂蛋白，特别是低密度脂蛋白氧化的结果。 具体目标： 本研究的目的是确定低密度脂蛋白（LDL）中脂质和蛋白质自由基氧化的机制。 从新鲜人血中分离LDL并将其暴露于自由基引发剂。 LDL氧化的产物被分离，并评估天然和人造抗氧化剂的效果。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Development of arterial plaque results from oxidation of lipoproteins, particularly low-density lipoproteins. SPECIFIC AIM: The objective of this study is to determine the mechanisms governing the free radical oxidation of lipids and proteins in low-density lipoproteins (LDL). LDL are isolated from fresh human blood and exposed to free redical initiators. Products of LDL oxidation are isolated and the effect of natural and man-made antioxidants are assessed.