CORRELATION ON THE PHARMACOKINETICS AND TOXICITY OF CPT-11 WITH FUNCTIONALLY

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Subjects with allelic variations in MRP2 that result in altered MRP2 transporter function will demonstrate altered pharmacokinetics and a different incidence of GI toxicity after treatment with CPT-11.