MUSC/HCC Paul Calabresi Clinical Oncology Career Development Program

项目总结/摘要 本申请旨在加强Paul Calabresi临床和转化肿瘤学培训计划， 南卡罗来纳州医科大学（MUSC）的Hollings癌症中心（HCC）-被称为 HCC Calabresi K12项目。Hollings癌症中心是美国唯一一家NCI指定的癌症中心。 南卡罗来纳州。发展创新和有影响力的临床和转化研究， 血液和实体肿瘤恶性肿瘤是HCC的最高战略目标。组织成几个强大的， 主题，跨学科的研究计划，HCC已经朝着这一目标取得了实质性进展。这 K12计划为下一代科学家提供了准备和加快翻译的机会 将科学带入临床。随着新的领导层，HCC正在进行战略扩张，重点是 关于招募和提升医学科学家的问题。虽然一个强大的癌症管道集中在 HCC-MUSC提供研究培训，从高中到本科，研究生和 博士后培训机会，HCC Calabresi K12计划是唯一由NCI资助的早期职业教师 南卡罗来纳州的发展项目。作为旗舰项目，它教育和培养初级调查员， 所谓的卡拉布雷西学者，在过渡到研究独立之前的关键时刻，在一个强大的 癌症研究人员之间的团队科学文化涵盖了广泛的学科。程序 建立在HCC和MUSC的突出优势之上，包括：1）强大的共享基础设施 研究资源; 2）多样化和不断增长的患者群体; 3）NIH资助的临床和转化 科学奖（CTSA）计划与临床研究科学硕士（MSCR）选项; 4）计划 教师导师，由基础和医生科学家组成，他们有良好的跟踪记录， 资助合作转化研究，5）转化癌症的主要机构投资 research.本申请中确定的40名课程教师导师和卡拉布雷西学者组成 HCC以病人为中心的研究的核心。

PROJECT SUMMARY / ABSTRACT This application proposes to enhance the Paul Calabresi Clinical & Translational Oncology Training Program at the Hollings Cancer Center (HCC) of the Medical University of South Carolina (MUSC) – referred to as the HCC Calabresi K12 Program. The Hollings Cancer Center is the only NCI-designated cancer center in the State of South Carolina. Development of innovative and impactful clinical and translational research in hematologic and solid tumor malignancies is the top strategic goal for the HCC. Organized into several strong, thematic, interdisciplinary research programs, the HCC has made substantial progress towards this goal. This K12 Program provides the next generation of scientists the opportunity to prepare and expedite the translation of science into the clinic. With new leadership, the HCC is undergoing strategic expansion, with an emphasis on the recruitment and advancement of physician-scientists. While a robust pipeline of cancer focused research training is offered at HCC-MUSC, which spans from high school to undergraduate, graduate and postdoc training opportunities, the HCC Calabresi K12 Program is the only NCI-funded early career faculty development program in South Carolina. As the flagship program, it educates and nurtures junior investigators, called Calabresi Scholars, at the critical juncture prior to transitioning to research independence in a strong culture of team science among cancer investigators encompassing a broad range of disciplines. The program builds on the outstanding strengths of the HCC and MUSC including: 1) a robust infrastructure of shared research resources; 2) a diverse and growing patient population; 3) a NIH funded Clinical and Translational Science Award (CTSA) program with a Master of Science in Clinical Research (MSCR) option; 4) Program Faculty Mentors, comprised of basic and physician scientists, who have well-established track records and funding in collaborative translational research, and 5) a major institutional investment in translational cancer research. The 40 Program Faculty Mentors identified in this application and the Calabresi Scholars constitute the core of patient-oriented research at the HCC.