RESPONSE TO PACLITAXEL RELATED TO GENITIC VARIATINS IN MDR1

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Specific aims are to evaluate the utility of fexofenadine levals as a predictor of MDR1 activity and paclitaxel pharmacokinetics, and to correlate the presence of allelic variations in MDR1 with paciltaxel pharmacokinetics.