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A PROBE STUDY OF THE SAFETY, TOLERABILITY AND IMMUNOGENICITY OF A THREE-DOSE

A PROBE STUDY OF THE SAFETY, TOLERABILITY AND IMMUNOGENICITY OF A THREE-DOSE
三剂安全性、耐受性和免疫原性的探索研究
批准号:
7375585
负责人:
PAUL W. SPEARMAN
金额:
$0.33万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2005
资助国家:
美国
项目状态:
已结题
起止时间:
2005-12-01 至 2006-11-30

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中文摘要
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英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. (1) Intramuscluar prime boost vaccination with the Ad5 HIV-1 gag vaccine will be generally safe and well-tolerated. (2) Four weeks after the boost vaccination with the Ad5 HIV-1 gag vaccine, at least one of the four vaccine dose groups will exhibit an immune response that is better than the placebo, based on the unfractionated gag-specific IFN-y ELISPOT assay.
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