EFFECTS OF AGE ON THE RESPONSE TO OXIDATIVE STRESS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。我们假设，在何种程度上的F2-异前列腺素，自由基介导的脂质过氧化反应的产品，增加血浆后前臂缺血/再灌注引起的充气和放气的血压袖带将提供一个准确的评估个人的总抗氧化能力，这是受损的老年人。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We hypothesize that the extent to which levels of F2-isoprostanes, products of free radical mediated lipid peroxidation, increase in plasma following forearm ischemia/reperfusion induced by inflating and deflating a blood pressure cuff will provide an accurate assessment of an individual's total antioxidant capacity and that this is impaired in the elderly.