THE F-MARS STUDY

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项先导性研究开发了评估可能影响血管功能的环境因素(饮食、体力活动和压力)和遗传因素(心血管疾病家族史和一些调节血管灵活性的基因)所需的工具。它们的再现性和有效性是在三代非裔美国家庭的背景下进行评估的。高血压病组包括先证者，即作为招募其家人的指标人的高血压患者、先证者S的配偶、8周岁及以上的子女、一级亲属和父母。控制者，即血压正常的人，在年龄和性别上与高血压先证者及其被招募形成正常血压的他/她的3代家庭相匹配。除了核心家庭成员(先证者、配偶和子女)第二次来诊所重复血管检查外，参与者只看一次面。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This pilot study develops instruments needed to assess environmental factors (diet, physical activity and stress) and genetic factors (family history of cardiovascular disease and a few genes that regulate vessel flexibility) that may impact on vascular function. Their reproducibility and validity are assessed in the context of three-generation African-American families. The hypertensive set includes the proband, i.e., the person with hypertension who serves as index person to recruit his/her family, the proband¿s spouse, offspring aged eight or more, first degree relatives, and parents. A control person, i.e, normotensive, is matched by age and gender to the hypertensive proband and his/her 3-generation family recruited to form the normotensive. The participants are seen once except for the members of the core family (proband, spouse and offspring) who come a second time to the clinic for repeat vascular exam