THE F-MARS STUDY

F-火星研究

• 批准号: 7381015
• 负责人: REBECCA DIN-DZIETHAM
• 金额: $ 9.77万
• 依托单位: MOREHOUSE SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7381015
• 关键词: MARS; STUDY

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This pilot study develops instruments needed to assess environmental factors (diet, physical activity and stress) and genetic factors (family history of cardiovascular disease and a few genes that regulate vessel flexibility) that may impact on vascular function. Their reproducibility and validity are assessed in the context of three-generation African-American families. The hypertensive set includes the proband, i.e., the person with hypertension who serves as index person to recruit his/her family, the proband¿s spouse, offspring aged eight or more, first degree relatives, and parents. A control person, i.e, normotensive, is matched by age and gender to the hypertensive proband and his/her 3-generation family recruited to form the normotensive. The participants are seen once except for the members of the core family (proband, spouse and offspring) who come a second time to the clinic for repeat vascular exam

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。这项试点研究开发了评估可能影响血管功能的环境因素（饮食，体力活动和压力）和遗传因素（心血管疾病家族史和一些调节血管灵活性的基因）所需的工具。在三代非裔美国家庭的背景下评估了其可重复性和有效性。高血压组包括先证者，即，高血压患者作为索引人招募他/她的家人，先证者的配偶，8岁或以上的子女，一级亲属和父母。对照组，即血压正常者，与高血压先证者及其3代家系按年龄和性别配对，组成血压正常者。除了核心家庭成员（先证者、配偶和子女）第二次来诊所重复血管检查外，参与者只看一次