THE F-MARS STUDY

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。这项初步研究开发了评估可能影响血管功能的环境因素（饮食、身体活动和压力）和遗传因素（心血管疾病家族史和一些调节血管灵活性的基因）所需的仪器。他们的再现性和有效性评估的背景下，三代非洲裔美国人的家庭。高血压组包括先证者，即以高血压患者为征召其家庭的指标人、先证者的配偶、8岁及以上子女、一级亲属、父母。对照者，即血压正常者，按年龄和性别与高血压先证者及其3代家族相匹配，形成血压正常者。除了核心家庭成员（先证者、配偶和后代）第二次来诊所重复血管检查外，参与者只见过一次

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This pilot study develops instruments needed to assess environmental factors (diet, physical activity and stress) and genetic factors (family history of cardiovascular disease and a few genes that regulate vessel flexibility) that may impact on vascular function. Their reproducibility and validity are assessed in the context of three-generation African-American families. The hypertensive set includes the proband, i.e., the person with hypertension who serves as index person to recruit his/her family, the proband¿s spouse, offspring aged eight or more, first degree relatives, and parents. A control person, i.e, normotensive, is matched by age and gender to the hypertensive proband and his/her 3-generation family recruited to form the normotensive. The participants are seen once except for the members of the core family (proband, spouse and offspring) who come a second time to the clinic for repeat vascular exam