META-HEALTH I

元健康I

• 批准号: 7381013
• 负责人: REBECCA DIN-DZIETHAM
• 金额: $ 11.73万
• 依托单位: MOREHOUSE SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7381013
• 关键词: META; HEALTH

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Over the past decade, there has been an explosive increase in obesity among all age groups within the US population. This epidemic is particularly problematic among AfricanAmericans in the Southeast. Although genetic factors play a contributory role, it is postulated that ethnic disparities in obesity and obesity-related cardiovascular disease (CVD) is related to a dynamic interplay between biological factors and the behavioral response to the unique environmental context within ethnic communities. Obesity is often associated with perturbations in the metabolic and physiologic milieu. A cluster of obesity-related abnormalities has been defined as the ¿Metabolic Syndrome¿. The CVD complications of obesity appears to be related to the capacity for adipose tissue itself to generate ¿adipokines¿ that directly predispose to insulin-resistance, endothelial dysfunction, inflammation and vascular disease. The proposed program will use state-of-the-art approaches to define potential ethnic differences in the profile of metabolic, physiologic and biochemical features associated with obesity as well as the salutary responses to lifestyle modification. The proposed program uses a multi-disciplinary strategy to systematically characterize potential ethnic differences in obesity-related CVD by drawing upon the fields of psychology, physiology, biochemistry, nursing and clinical medicine. In a thematic series of inter-related studies, our Program¿s research plan ranges from: epidemiology studies within the ethnic communities, to patient-centered clinical trial interventions within ethnic community practices, to the analysis of novel biomarkers of human pathobiology. This collaborative multi-investigator team is built upon a complementary partnership between the Morehouse School of Medicine and Emory University. This partnership shares a joint commitment to address the striking ethnic disparities in the high-risk CVD population that we serve. The specific aims are: Aim 1: Define the relative influence of psychosocial/cultural factors and biological mediators as determinants of ethnic disparities in obesity and the metabolic syndrome in a population-based bi-racial cohort. Aim 2: Define the effectiveness of patient-targeted behavioral interventions to enhance the health of African-American patients with the Metabolic Syndrome in the context of community-based clinical practices. Aim 3: To assess the impact of innovative lifestyle intervention strategies on conventional and novel biomarkers of vascular disease risk in African-Americans. Aim 4: To enhance the education/training of fellows/practitioners engaged in CVD disparities research/practice and promote partnerships that enhance cardiovascular health within ethnic communities.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构是针对该中心的，这不是调查人员的机构。在过去的十年中，美国人口中所有年龄段的肥胖症都在爆炸性增加。这种流行病在东南部的非裔美国人中尤其有问题。尽管遗传因素发挥了作用，但据推测，肥胖和与肥胖相关的心血管疾病（CVD）中的种族分布与生物学因素之间的动态相互作用与对种族社区中独特环境环境的行为反应之间的动态相互作用有关。肥胖通常与代谢和生理环境中的扰动有关。一群与肥胖相关的异常已被定义为“代谢综合征”。肥胖的CVD并发症似乎与脂肪组织本身产生脂肪因子的能力有关，脂肪因子直接易受胰岛素抗性，内皮功能障碍，炎症和血管疾病。该计划将使用最先进的方法来定义与肥胖相关的代谢，生理和生化特征以及对生活方式修改的有益反应的潜在种族差异。拟议的计划使用多学科策略来系统地表征与肥胖相关CVD潜在的种族差异，通过利用心理学，生理学，生物化学，护士和临床医学领域。在一系列相关研究的主题系列中，我们的计划的研究计划范围从：族裔社区内的流行病学研究到族裔社区实践中以患者为中心的临床试验干预措施到人类病理生物学的新生物标志物的分析。这个合作的多入侵者团队建立在莫尔豪斯医学院和埃默里大学之间的互补伙伴关系基础上。该合作伙伴关系共同承诺解决我们服务的高风险CVD人群中的族裔差异。具体目的是：目标1：定义心理社会/文化因素和生物学介体的相对影响，是肥胖症中种族差异的确定因素和基于人群的双种族同胞中的代谢综合征。 AIM 2：定义针对患者的行为干预措施的有效性，以增强基于社区的临床实践的背景下，可以增强非裔美国人患有代谢综合征的患者的健康。目标3：评估创新的生活方式干预策略对非裔美国人血管疾病风险的常规生物标志物的影响。目标4：增强从事CVD差异研究/实践的研究员/从业人员的教育/培训，并促进伙伴关系，以增强族裔社区的心血管健康。