META-HEALTH I

元健康I

• 批准号: 7381013
• 负责人: REBECCA DIN-DZIETHAM
• 金额: $ 11.73万
• 依托单位: MOREHOUSE SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7381013
• 关键词: META; HEALTH

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Over the past decade, there has been an explosive increase in obesity among all age groups within the US population. This epidemic is particularly problematic among AfricanAmericans in the Southeast. Although genetic factors play a contributory role, it is postulated that ethnic disparities in obesity and obesity-related cardiovascular disease (CVD) is related to a dynamic interplay between biological factors and the behavioral response to the unique environmental context within ethnic communities. Obesity is often associated with perturbations in the metabolic and physiologic milieu. A cluster of obesity-related abnormalities has been defined as the ¿Metabolic Syndrome¿. The CVD complications of obesity appears to be related to the capacity for adipose tissue itself to generate ¿adipokines¿ that directly predispose to insulin-resistance, endothelial dysfunction, inflammation and vascular disease. The proposed program will use state-of-the-art approaches to define potential ethnic differences in the profile of metabolic, physiologic and biochemical features associated with obesity as well as the salutary responses to lifestyle modification. The proposed program uses a multi-disciplinary strategy to systematically characterize potential ethnic differences in obesity-related CVD by drawing upon the fields of psychology, physiology, biochemistry, nursing and clinical medicine. In a thematic series of inter-related studies, our Program¿s research plan ranges from: epidemiology studies within the ethnic communities, to patient-centered clinical trial interventions within ethnic community practices, to the analysis of novel biomarkers of human pathobiology. This collaborative multi-investigator team is built upon a complementary partnership between the Morehouse School of Medicine and Emory University. This partnership shares a joint commitment to address the striking ethnic disparities in the high-risk CVD population that we serve. The specific aims are: Aim 1: Define the relative influence of psychosocial/cultural factors and biological mediators as determinants of ethnic disparities in obesity and the metabolic syndrome in a population-based bi-racial cohort. Aim 2: Define the effectiveness of patient-targeted behavioral interventions to enhance the health of African-American patients with the Metabolic Syndrome in the context of community-based clinical practices. Aim 3: To assess the impact of innovative lifestyle intervention strategies on conventional and novel biomarkers of vascular disease risk in African-Americans. Aim 4: To enhance the education/training of fellows/practitioners engaged in CVD disparities research/practice and promote partnerships that enhance cardiovascular health within ethnic communities.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中得到体现。列出的机构是中心的机构，不一定是研究者的机构。在过去的十年中，美国人口中所有年龄段的肥胖率都呈爆炸式增长。这种流行病在东南部的非裔美国人中尤其成问题。尽管遗传因素发挥着重要作用，但据推测，肥胖和肥胖相关心血管疾病（CVD）的种族差异与生物因素和种族社区内独特环境背景的行为反应之间的动态相互作用有关。肥胖通常与代谢和生理环境的扰动有关。一系列与肥胖相关的异常被定义为“代谢综合症”。肥胖引起的心血管疾病并发症似乎与脂肪组织本身产生“脂肪因子”的能力有关，“脂肪因子”直接导致胰岛素抵抗、内皮功能障碍、炎症和血管疾病。拟议的计划将使用最先进的方法来定义与肥胖相关的代谢、生理和生化特征的潜在种族差异，以及对生活方式改变的有益反应。该项目采用多学科策略，通过心理学、生理学、生物化学、护理和临床医学领域，系统地描述肥胖相关心血管疾病的潜在种族差异。在一系列相互关联的主题研究中，我们项目的研究计划范围包括：种族社区内的流行病学研究，种族社区实践中以患者为中心的临床试验干预，以及人类病理学新生物标志物的分析。这个多研究者合作团队是建立在莫尔豪斯医学院和埃默里大学之间互补的伙伴关系基础上的。这种伙伴关系共同致力于解决我们所服务的高危心血管疾病人群中显着的种族差异。具体目标是： 目标 1：将心理社会/文化因素和生物调节因素的相对影响定义为基于人群的双种族队列中肥胖和代谢综合征种族差异的决定因素。目标 2：确定以患者为目标的行为干预措施的有效性，以在基于社区的临床实践中增强非裔美国代谢综合征患者的健康。目标 3：评估创新生活方式干预策略对非裔美国人血管疾病风险的传统和新型生物标志物的影响。目标 4：加强对从事心血管疾病差异研究/实践的研究员/从业人员的教育/培训，并促进加强种族社区内心血管健康的伙伴关系。