S-MARS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。该项目的一个主要目标是描述成人肥胖患者血管疾病早期、亚临床阶段血管基因表达异常的特征，并评估其相关性以及血管功能障碍与血管基因表达之间潜在的病理生物学中介途径。虽然令人信服的证据表明，遗传和其他生物因素容易导致肥胖和高血压，但这些常见的共生疾病可能反映了生物因素与心理社会和文化环境之间的复杂相互作用。总而言之，这一系列研究将是第一批将人类血管mRNA表达谱的变化与血管功能和肥胖的生理变化联系起来的研究之一。总体而言，预计这些实验将为高危非裔美国人肥胖受试者血管僵硬和内皮功能障碍的分子基础提供新的见解。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A major objective of this project is to characterize the abnormalities of vascular gene expression occurring in early, subclinical stages of vascular disease, as assessed by large artery function, in adult obesity and to assess its correlates and the potential pathobiological mediating pathways between vascular dysfunction and vascular gene expression. While compelling evidence indicates that genetic and other biological factors predispose to obesity and hypertension, these common, co-occurring disorders likely reflect a complex interplay between biological factors and the psychosocial and cultural environment. Taken together, this series of studies will be among the first to link changes in human vascular mRNA expression profiles with physiologic alterations in vascular function and obesity. Overall, it is anticipated that these experiments will provide new insights into the molecular basis of vascular stiffness and endothelial dysfunction in high-risk AfricanAmerican obese subjects.