S-MARS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。该项目的一个主要目标是描述在成人肥胖症中，通过大动脉功能评估的血管疾病早期亚临床阶段血管基因表达的异常，并评估其相关性和血管功能障碍与血管基因表达之间潜在的病理生物学介导途径。虽然令人信服的证据表明，遗传和其他生物因素易患肥胖和高血压，这些常见的，共同发生的疾病可能反映了生物因素和心理社会和文化环境之间的复杂相互作用。总之，这一系列的研究将是第一个在人类血管mRNA表达谱的变化与血管功能和肥胖的生理改变联系起来。总体而言，预计这些实验将提供新的见解血管硬度和内皮功能障碍的分子基础，在高危AfricanAmerican肥胖受试者。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A major objective of this project is to characterize the abnormalities of vascular gene expression occurring in early, subclinical stages of vascular disease, as assessed by large artery function, in adult obesity and to assess its correlates and the potential pathobiological mediating pathways between vascular dysfunction and vascular gene expression. While compelling evidence indicates that genetic and other biological factors predispose to obesity and hypertension, these common, co-occurring disorders likely reflect a complex interplay between biological factors and the psychosocial and cultural environment. Taken together, this series of studies will be among the first to link changes in human vascular mRNA expression profiles with physiologic alterations in vascular function and obesity. Overall, it is anticipated that these experiments will provide new insights into the molecular basis of vascular stiffness and endothelial dysfunction in high-risk AfricanAmerican obese subjects.