S-MARS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。该项目的一个主要目标是描述成人肥胖中发生在血管疾病早期亚临床阶段的血管基因表达异常，通过大动脉功能评估，并评估其相关性以及血管功能障碍和血管基因表达之间的潜在病理生物学介导途径。虽然令人信服的证据表明遗传和其他生物因素易导致肥胖和高血压，但这些共同发生的疾病可能反映了生物因素与社会心理和文化环境之间复杂的相互作用。综上所述，这一系列研究将是第一个将人类血管mRNA表达谱的变化与血管功能和肥胖的生理改变联系起来的研究。总之，预计这些实验将为高危非裔美国人肥胖受试者血管僵硬和内皮功能障碍的分子基础提供新的见解。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A major objective of this project is to characterize the abnormalities of vascular gene expression occurring in early, subclinical stages of vascular disease, as assessed by large artery function, in adult obesity and to assess its correlates and the potential pathobiological mediating pathways between vascular dysfunction and vascular gene expression. While compelling evidence indicates that genetic and other biological factors predispose to obesity and hypertension, these common, co-occurring disorders likely reflect a complex interplay between biological factors and the psychosocial and cultural environment. Taken together, this series of studies will be among the first to link changes in human vascular mRNA expression profiles with physiologic alterations in vascular function and obesity. Overall, it is anticipated that these experiments will provide new insights into the molecular basis of vascular stiffness and endothelial dysfunction in high-risk AfricanAmerican obese subjects.