HYPERTENSION, OXIDATIVE STRESS AND RACE

高血压、氧化应激和种族

• 批准号: 7381054
• 负责人: ZHONGMAO GUO
• 金额: $ 16.11万
• 依托单位: MEHARRY MEDICAL COLLEGE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7381054
• 关键词: HYPERTENSION; OXIDATIVE; STRESS; RACE

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Studies show that hypertension, also known as high blood pressure, occurs more commonly in African-Americans than in Caucasians. For this reason, this study will focus on hypertension in African-Americans and examine factors that may cause hypertension to be found more often in this population. The factor that will be examined in this study is a condition known as oxidative stress. Oxidative stress is a condition where too much oxygen is produced in the blood and the cells begin to decline in quality. Two chemicals, such as, reactive oxygen species (ROS) and F2-isoprostane, when found in high levels in the blood, can cause this condition. The purpose of this study is to measure these chemicals and determine if African-Americans with high blood pressure have higher levels of these chemicals than in subjects with normal blood pressure readings.

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。研究表明，高血压，也称为高血压，在非裔美国人中比在高加索人中更常见。出于这个原因，这项研究将重点放在非裔美国人的高血压上，并检查可能导致高血压在这一人群中更常见的因素。这项研究将考察的因素是一种被称为氧化应激的情况。氧化应激是一种血液中产生太多氧气，细胞质量开始下降的情况。两种化学物质，如活性氧物种(ROS)和F2-异前列腺素，当在血液中发现高水平时，可导致这种情况。这项研究的目的是测量这些化学物质，并确定患有高血压的非裔美国人是否比血压正常的受试者有更高的这些化学物质水平。